Past Events

Events of 2000/01.

CRC-CGF Sponsored Meetings
    Molecular Modelling Workshop
    Bioinformatics Course
    Biosensor Workshop at Lorne
CRC-CGF Workshops
    International Workshop
    Proteomics and Drug Discovery Workshop
    FACS Workshop
Interactions with the Public
    CRC-CGF World Wide Web Site
    Presentation to Osborne Associates
    Biotechnology for Funds Managers
    Science Meets Art in ‘Genetically Modified Ps’
    DETYA/Universtity of Melbourne Lectureship Brochure
    Royal Melbourne Hospital Research Week
    CRC Association Annual Conference
    Public Lectures
Visits to the CRC-CGF
    Lindsay Tanner, MP
    Katherine Murphy
    Visiting Scientists

Events of 2001/02.

CRC-CGF Sponsored Meetings
    Molecular Modelling Workshop
    Bioinformatics Course
CRC-CGF Workshops
    Protein Expression Workshop
    RasMol Workshop
    Proteomics Workshop
Interactions with the Public
    CRC-CGF Web Site
    Genetech 2002
    Great Australian Science Show
    Interaction with Investment Group BBY
    CRC Association Annual Conference
    Science Meets Parliament
Visits to the CRC-CGF
    Polytechnic Tour of AMRAD
    Visiting Scientists

Events of 2002/03

CRC-CGF Sponsored Meetings
    Bioinformatics Course
CRC-CGF Workshops
    Protein Expression Workshop
    The Chip Technology Series
Interactions with the Public
    CRC-CGF World Wide Web Site
    Genetech 2003
    Rotary Presentations
    DEST/University of Melbourne -

    Lectureship Brochure
    Careers Upgrade Fair 2002
    CRC Association Annual Conference
    Science Meets Parliament Day
Visits to the CRC-CGF
    Anna Burke, MP

    Indian Education Tour
    Japanese Society for the Promotion

    of Science

 


 

2000/01.

 

CRC-CGF Sponsored Meetings

Three meetings for describing and demonstrating advances in specialist technologies were supported by the CRC-CGF this year.

Molecular Modelling Workshop

The 6th Australian Molecular Modelling Workshop (MM2000) was held in Melbourne at RMIT University from 5–8 December. This Workshop has become a major forum for Australian researchers working in computational chemistry, physics, biology, materials science and drug design. MM2000 was jointly organised by a number of CRC-CGF staff from LICR and BRI. The CRC-CGF also provided sponsorship to assist in attracting expert speakers to the event.

Bioinformatics Course

The success of last year’s week-long Bioinformatics Short Course for Postgraduate Students was followed up by the planning and delivery of a second Bioinformatics Course in August 2000. The course examined the background, concepts and techniques for effective use of genetic, protein and biological databases. As with last year, the format of the course was a combination of lectures that were open to all interested researchers and hands-on practical sessions that were restricted to postgraduate students.

Approximately one hundred people attended each of the Bioinformatics lectures. Among the presenters were CRC-CGF members Prof. Antony Burgess (LICR), Dr Tom Garrett (BRI), Dr Herbert Treutlein (LICR) and Dr Richard Simpson (LICR/WEHI). Twenty students participated in the course (over 40 applications were received) and this included CRC-CGF postgraduate student, Denise Bullen. The course was sponsored and run as a collaborative effort between LICR, the Howard Florey Institute and the CRC-CGF. The main organisers for the event were Dr Nathan Hall and Dr Cassandra Thumwood (both CRC-CGF/LICR). The Course dinner was sponsored by Advanced Laboratory Solutions.

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Biosensor Workshop at Lorne

As in previous years, the CRC-CGF and the CRC for Diagnostic Technologies were the major sponsors of the Specialist Workshop on ‘Biosensor and Alternative Technologies for the Study of Macromolecular Interactions’, which was held at Erskine House, Lorne as a satellite meeting prior to the 30th Lorne Conference on Protein Structure and Function in February 2000. The meeting, which was attended by over seventy delegates, had a number of international speakers including Dr Bill Rich from Ciphergen Biosystems Inc., USA, and Dr Bill Gelg of MicroCal, USA. Sessions included Emerging Applications of Chop Technology, Alternative Methodologies for Studying Protein-Protein Interactions and Biosensor Applications. CRC-CGF members Assoc. Prof. Ed Nice (LICR) and Dr Louis Fabri (AMRAD) gave presentations at the Workshop. In addition Assoc. Prof. Ed Nice chaired one of the sessions and was a member of the organising committee. BIAcore AB, Advanced Laboratory Solutions, Beckman Coulter, Packard BioScience and MicroCal sponsored the event.

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CRC-CGF Workshops

To assist researchers in keeping up-to-date with the latest developments in research and laboratory techniques, three workshops were organised by the CRC-CGF during the year.

International Workshop

The International Workshop on ‘Cytokines and Signal Transduction – Molecular Regulation of Growth and Development’ was held in November and was attended by most CRC-CGF members. The Workshop was sponsored by AMRAD.

The scientific program included numerous presentations from international speakers as well as presentations from CRC-CGF members and local scientists. The international speakers were Dr Nils Billstrup (Denmark), Dr Joelle Finidori (France), Dr Christin-Carter-Su (USA), Dr Ger Strous (Netherlands), Dr Helen Davey (New Zealand), Dr Sif Groth Larson (Denmark), Henrijette Richter (Denmark) and Dr Marc Edery (France). Presentations were also given by local scientists Dr Chris Greenhalgh (CRC-CGF/WEHI), Dr Jane Visvader (WEHI), Dr Warren Alexander (CRC-CGF/WEHI) and Dr Colin Ward (CRC-CGF/CSIRO)

There was an extensive social program associated with the Workshop that included a dinner at WEHI and a tour along the Great Ocean Road. CRC members escorted most of the overseas guests on the tour, which culminated in lunch at Skenes Creek on the South Western Victorian coastline.

The scientific program for the International Workshop was organised by Dr Helene Martin (CRC-CGF/WEHI) and Dr Doug Hilton (CRC-CGF). Further CRC-CGF members of the Planning Committee were Leecia Angus, Dale Cary (WEHI), Roslyn Clark, Dr Nathan Hall (LICR), Assoc. Prof. Ed Nice (LICR) and Julie Rothacker (LICR).
Proteomics and Drug Discovery Workshop

The CRC-CGF in partnership with LICR hosted the ‘Developments in Proteomics and Drug Discovery Workshop’. This Workshop was of particular interest to researchers studying protein-protein interactions and proteomics. Speakers at the Workshop were Dr Chris Williams from Millennium Pharmaceuticals, USA, who described proteomic applications for BIAcore biosensors, and Dr Robert Karlsson from BIAcore AB, Sweden, who gave a talk entitled ‘BIAcore in the Drug Discovery Process: Applications for Drug-target Characterisation and Assays for Prediction of ADME Properties’. The Workshop was held at WEHI in November and attracted approximately seventy participants. Sponsors for the event were BIAcore AB.


Dr Chris Williams describing proteomic applications for BIAcore biosensors at the Proteomics and Drug Discovery Workshop

 

FACS Workshop

Fluorescent Activated Cell Sorting (FACS) is a technique used by many researchers, particularly cell biologists. To assist researchers to master this technique and adapt it to their own needs, the CRC-CGF organised a FACS Workshop. The Workshop was led by WEHI’s Head of the Flow Cytometry Laboratory, Dr Frank Battye, and had a two-part program: the first session provided an introduction to FACS and the second part focused on troubleshooting. Twenty-seven researchers participated in the Workshop, which was held at WEHI. The Workshop was organised by Leecia Angus (CRC-CGF) and Julie Rothacker (CRC-CGF/LICR).

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Interactions with the Public

CRC-CGF World Wide Web Site

The CRC-CGF maintains a web site providing information about the Centre and its contact details. Structure and research programs of the Centre, forthcoming events and education programs such as the Undergraduate Research Opportunities Program are displayed on the site. The CRC-CGF web master is Dr Nathan Hall from LICR.

Presentation to Osborne Associates

In January Dr Greg Wilson spoke to the Melbourne Financial Services Consultants’ Meeting (also known as The Osborne Associates) about biotechnology and CRCs developing biotechnology applications.

The aim of Financial Services Consultants’ meetings is to facilitate networking, clustering and business development amongst boutique advisory firms that operate in Melbourne, Australia and internationally. Participants in the group include executives involved in strategy and business development, financing, funds management, venture capital, banking, derivatives and structured financial products and human resources.

Ten people attended and Dr Wilson received many questions on a variety of aspects of biotechnology. This event was organised as part of the DETYA Lectureship Program (see Cooperative Linkages). Dr Wilson is employed by this program as a Biotechnology Education and Training Officer and he delivers education for the five CRCs involved.

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Biotechnology for Funds Managers

In February, an event called ‘Biotechnology for Funds Managers’ was organised in collaboration with the Securities Institute of Australia. The audience of approximately one hundred people, the majority of whom were from the fund managers’ industry, listened to Prof. Adrienne Clarke (CRC for Bioproducts), Prof. Graham Mitchell (CRC-VT and Gene CRC) and Dr Doug Hilton (CRC-CGF) speak about investment into biotechnology. This was followed by talks from panel members Dr Amanda Caples (CRC-CGF/AMRAD), Dr David Ryan (CSL Ltd), Dr Vivien Santer (Griffith Hack) and Ms Brigette Smith (Rothschild Bioscience Unit) about biotechnology, licensing and investment in biotechnology. The panel also led discussion with the audience. The event was held at the Grand Hyatt Hotel, Melbourne, and was convened by Dr Greg Wilson from The University of Melbourne and Ms Bronwen Murdoch from the Securities Institute of Australia.

From the questionnaire data collected at ‘Biotechnology for Funds Managers’, most of the participants thought the sessions made very worthwhile contributions to their professional development, both at individual and organisational levels. A significant number of finance respondents (more than 55%) also indicated that they would be willing to consider a professional relationship with a CRC and/or an Australian biotechnology venture. The feedback received about the quality and content of the presentations was extremely positive enabling us to conclude that the seminar was a resounding success.


The former CRC-CGF Director, Dr Douglas Hilton, addresses the audience (right) at the 'Biotechnology for Funds Managers" event orgainsed through the Securities Institute of Australia
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Science Meets Art in 'Genetically Modified Ps'

In an event designed to raise awareness of the issues surrounding biotechnology, a science-based art competition was organised through the DETYA/University of Melbourne Lectureship Program. The event showcased Victorian Year 9 – 12 students’ artworks on the theme of ‘Genetically Modified Ps’. Students were invited to enter in several categories including Pictures, Pottery, Poetry, 'Puters and …Peas! Numerous entries were received and depicted a wide range of differing perceptions about the impact of biotechnology on life forms and products.

One of the winning entries, called ‘Peas for Packaging’, came from South Oakleigh Secondary College in Melbourne. This large motorised creation was obviously fun to make and showed a wide variety of genetic effects with some peas turning out square, ideal for packing, and others being complete misfits with Barbie Doll legs, eyes and other types of mutations. Students from Wanganui Park Secondary College in Shepparton were also finalists with a clever series of photographs showing square peas in a pod, multi-coloured peas in a pod and a number of large orange peas in pods cupped caringly in a pair of young hands.

Prof. Peter Doherty was a keynote speaker together with the Director of WEHI, Prof. Suzanne Cory, at a public seminar, ‘Biotechnology - will you be part of the excitement?’ in which students from Methodist Ladies’ College and Balwyn High School debated whether genetically modified organisms are good for you. A media release about the ‘Genetically Modified P’s’ art competition and debate was prepared and published in the Education Times.

DETYA/Universtity of Melbourne Lectureship Brochure

In order to publicise the role of the CRCs and The University of Melbourne in public forums organised through the Lectureship Program, a brochure has been produced. The brochure explains what the Program’s aims are, what biotechnology is and individual CRC aims. Details of the CRCs participating in this Program are given in Cooperative Linkages.

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Royal Melbourne Hospital Research Week

Again this year, members of the CRC-CGF participated in the Royal Melbourne Hospital (RMH) Research Week. This annual event showcases the research activities carried out at the Hospital and its associated institutes including WEHI and LICR. Julie Rothacker (CRC-CGF/LICR) was awarded the Cleveland Young Investigator’s Award for the oral presentation she gave at RMH Research Week.

CRC Association Annual Conference

The CRC-CGF Director, Dr Doug Hilton, and the chair of the CRC-CGF Education and Training Committee, Dr George Lovrecz (CRC-CGF/CSIRO), attended this year’s CRC Association Annual Conference. The conference and its associated satellite meetings were held over three days in Perth, Western Australia.

Public Lectures

Members of the CRC-CGF have given talks in community forums during the year. In August, Dr Warren Alexander (WEHI) was invited to speak at the BizScience Biotechnology Forum in Melbourne. In October, Dr Colin Ward gave a general talk on the role of molecular and structural biology in health research to the Coburg Probus Club, Melbourne, and in June, Leecia Angus gave a talk entitled ‘CRCs – Converting New Knowledge into New Product’ to the University of the Third Age in Sunbury, Victoria.

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Visits to the CRC-CGF

Lindsay Tanner, MP

The CRC-CGF was fortunate to be visited by Mr Lindsay Tanner during September. Mr Tanner is the Federal Member for Melbourne and is also the Shadow Minister for Finance and Shadow Minister for Consumer Affairs. Mr Tanner was informed about the activities of the Centre through two presentations and an informal morning tea. The presenters were Dr Doug Hilton and Dr David Crump (AMRAD). Mr Tanner toured CRC-CGF laboratories in WEHI and enjoyed learning about Prof. Don Metcalf’s work researching the actions of growth factors.

 


Prof. Don Metcalf and Dr Douglas Hilton meeting with Mr Lindsay Tanner, MP

Katherine Murphy

Ms Katherine Murphy from the Prime Minister’s Office visited the CRC-CGF at WEHI in June. Ms Murphy is senior advisor to the Prime Minister of Australia, the Hon. John Howard MP. Her portfolio responsibilities are extensive and include science and technology.

The visit began with a briefing between Ms Murphy and the CRC-CGF Director, Dr Doug Hilton, and was followed by a series of presentations. The presenters were Dr Andrew Nash (CRC-CGF/AMRAD) who talked about negative regulators of cytokine signalling SOCS, Prof. Antony Burgess (CRC-CGF/LICR) who described the Centre’s research on the growth factor EGF, and Dr Lorraine Robb (CRC-CGF/WEHI) who described her team’s work on the growth factor IL-11. Emily Friedel also gave a presentation, which was about her experience as an Undergraduate Research Opportunities Program in the CRC-CGF.

Following the presentations, an afternoon tea was held to enable candid discussion of issues pertinent to medical research.

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Visiting Scientists

Prof. Jim Staros, Professor and Chair of Biological Sciences, Professor of Molecular Biology and Professor of Biochemistry at the Vanderbilt University, Nashville, Tennessee visited Prof. Tony Burgess and his team at LICR, where he gave a presentation of his latest results on the EGF/EGFR system. Prof. Bill Gullick, who is currently Professor of Cancer Biology, Department of Biosciences, University of Kent at Canterbury, and President Elect of the Federation of European Cancer Societies, also gave a lecture at LICR, and visited the laboratories of Prof. Tony Burgess and Assoc. Prof. Ed Nice. Prof. Gullick was visiting Australia as an Invited Speaker for the Granet Passe ‘Frontiers on Otorhinolaryngology 2000’ meeting in Adelaide.

 

 

 

 

2001/02

 

CRC-CGF Sponsored Meetings

The following meetings were supported by the CRC-CGF this year.

Molecular Modelling Workshop

The 7th Australian Molecular Modelling Conference was held from the 4th to the 7th October, 2001, at the Australian National University in Canberra. This year’s conference added to the successes built over previous years since its inception as a solely CRC-CGF-organised event in 1994. The program covered a range of topics including Biomolecular Simulation, Drug Design and Docking, and included a session on R & D Modelling in Industry. A number of CRC-CGF personnel attended and presented their work, including Dr Robert Jorissen and Dr Nathan Hall from LICR, and Kim Branson (CSIRO and WEHI), whose registration was funded through the CRC-CGF education program. The CRC-CGF once again provided sponsorship to assist in attracting expert speakers.

Bioinformatics Course

Twenty-four postgraduate students selected from over 50 applicants participated in the third Bioinformatics Workshop which was held over September 3rd to 7th, 2001. Half of the participants were from interstate and the remainder were from Melbourne, with three of these being CRC-CGF members. The program consisted of lectures in the morning, which were open to the public. Approximately 70 – 100 people attended each of the lectures and these were held at the Howard Florey Institute. The afternoon sessions were only available to the 24 selected students and consisted of detailed tutorials and guided practicals in WEHI’s recently finished Bioinformatics Laboratory. The areas covered included an overview of databases, sequence alignment, searching, protein structure, proteomics and microarrays. Several CRC-CGF members were among the presenters, including Prof. Antony Burgess (LICR), Dr Colin Ward (CSIRO), Dr Tom Garrett (WEHI), Dr Nathan Hall (LICR), Prof. Suzanne Cory (WEHI) and Dr Richard Simpson (WEHI/LICR). The course was supported by Applied Biosystems, who kindly sponsored the dinner held on the Thursday evening, and was a collaborative effort between LICR, the Howard Florey Institute and the CRC-CGF. Dr Robert Flegg, with assistance from colleagues Drs Cassandra Thumwood and Nathan Hall (both CRC-CGF/LICR), was employed as the main organiser, and once again feedback from the workshop was very positive.

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CRC-CGF Workshops

To assist researchers in keeping up-to-date with the latest developments in research and laboratory techniques, the following workshops were organised by the CRC-CGF during the year.

Protein Expression Workshop

The Protein Expression Workshop, hosted by the CRC-CGF and CSIRO was held at CSIRO’s Parkville site in August 2001. This two-day workshop attracted over 100 registrants from both academic and commercial organisations in Victoria, Queensland, NSW and South Australia. The workshop covered the processes involved in the successful production of recombinant glycoproteins, a procedure which requires a range of skills and disciplines, including molecular biology, fermentation, protein purification, crystallisation and structural analysis. The program on Day One included topics such as mammalian expression systems, insect cell cultures, both small and large-scale production of proteins and purification systems. On Day Two, the program focussed on large-scale equipment such as bioreactors, filtration and purification and a ‘hands-on’ practical session. Both days concluded with refreshments and pizza. A number of CRC-CGF staff presented at the workshop, including Dr George Lovrecz, the organiser, along with Drs Tim Adams, Douglas Hilton, Jose Varghese, Assoc. Prof. Ed Nice and a brief introduction was given by Leecia Angus.

RasMol Workshop

The RasMol Workshop was held specifically for CRC-CGF members in August 2001 at WEHI. The workshop had seven attendees ranging from UROP students to senior scientists. It was conducted by Dr Robert Jorissen and Dr Nathan Hall (both from LICR) and consisted of a half-day practical session to introduce the bench scientist to structural biology through molecular visualisation. The RasMol computer program serves to guide the user through a series of protein structures with practical examples of mutation data analysis, binding site analysis and very basic homology modelling exercises.

Proteomics Workshop

The CRC-CGF combined with co-sponsor Agilent Technologies Life Sciences to hold a workshop entitled “A Proteomics Update”. This was held at WEHI on 21st February 2002 and addressed current trends in proteomics and life sciences as well as new strategies, platforms and applications for proteomics. The two speakers were Dr Alex Apffel and Dr John Michnowicz, both from Agilent Technologies. Dr Apffel is currently a Senior Research Scientist focussing on the application of novel approaches in analytical biochemistry and mass spectrometry to proteomics. Dr Michnowicz is an analytical chemist experienced in mass spectrometry products and is currently the Proteomics Manager for Agilent with an interest in integrating new technologies. He outlined the commercial rationale behind the marketing directions that the major instrument companies are following. The workshop was attended by over 60 scientists representing the CRC-CGF, other locally based CRCs, Melbourne universities and the local biotechnology industry. There was stimulating discussion following each presentation, which continued at the social mixer where delegates had ample opportunity to interact with the presenters while enjoying light refreshments provided by Agilent Technologies.
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Interactions with the Public

CRC-CGF World Wide Web Site

The CRC-CGF maintains a web site providing information about the Centre and its contact details. The information displayed includes the structure and research programs of the Centre, forthcoming events and education programs such as UROP as well as links to the CRC Program, DEST and other related CRCs and research organisations. The CRC-CGF web-site is maintained by Dr Nathan Hall and Joshua McDonald, a UROP student, both from LICR. As part of his UROP project, Joshua McDonald recently redesigned and updated the web-site to give it a more vibrant and user-friendly appearance.

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Genetech 2002

The Biotechnology Education and Training Program (BETP, comprising Programs 6 & 7 of the Lectureship Program), combined with the participant CRCs, the Melbourne Museum and The Gene Technology Access Centre, held a week-long event called ‘Genetech 2002’ from 13th – 19th May. Genetech 2002 included a range of activities designed for primary and secondary school students, teachers as well as the general public. The week was designed to showcase Victorian initiatives in Biotechnology Education and many events were organised such as public lectures, workshops, symposia, competitions and displays.

The CRC-CGF’s new Director Dr John Flack and Prof. Ashley Dunn were among the speakers at the Opening Ceremony of Genetech held at the Melbourne Museum. A DNA Science Workshop for Public Leaders followed at the GTAC Laboratories (The University High School and WEHI), on Wednesday 15th May, attracting a group of leaders keen to learn more about DNA. The workshop was designed for non-scientists and aimed to inform public leaders from non-scientific organisations with the potential to impact significantly on the biotechnology industry.

The week also included two public lectures at the Melbourne Town Hall organised in conjunction with the City of Melbourne. The first lecture, entitled “Genetically Modified Organisms – Monsters or Miracles?”, addressed questions about environmental health and economic benefits. The speakers were Dr Eric Huttner from the Centre for the Application of Molecular Biology to International Agriculture, Canberra, Mr Scott Kinnear, a member of The Greens Victoria and Spokesperson for Biological Farmers of Australia Co-Op, and Prof. Peter Langridge from The Faculty of Agricultural and Natural Resource Sciences, Waite Campus, Adelaide University. The Moderator was the Honourable Dr Barry Jones. This event was supported by The Australian-French Association of Professional and Technical Specialists (AFAS).

The second lecture in the series was entitled “Gene Choices – Genetics for Humans”, and covered the moral mazes surrounding prenatal genetic testing and reproduction in Australia. The speakers at this event were the Rev. Tim Costello of the Baptist Union of Australia, Prof. Bob Williamson from the Murdoch Children’s Research Institute and Dr Tom Shakespeare from the Policy, Ethics and Life Sciences Research Institute in the UK, with Dr Andi Horvath as moderator. Both events were very well attended with audiences at full capacity, and many people took part in the discussion afterwards.

There was also a commercialisation seminar, “Biotechnology in the New Economy”, held at The University of Melbourne specifically for scientists. This seminar concentrated on the health and economic benefits of biotechnology to Australia and was presented by Dr Eric Huttner and Dr Doug Anderson from Austrade. The session was well attended by CRC members and was supported by both AFAS and the Australian Innovation Festival.

Genetech 2002 also held an art competition with the theme “Biotechnology Meets Art”. Students had the opportunity to produce artistic expressions of their day’s activities in biotechnology at The Melbourne Museum. An Awards Ceremony, featuring a talk by Dr Tom Shakespeare, was held at The Melbourne Museum on Friday 17th May. This session also included a debate between MacRobertson Girls’ High and Balwyn High School on “To Clone or Not to Clone”.

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Left: MacRobertson Girls' High School versus Balwyn High School in the Genetech Debate "To Clone or not to Clone", hosted by Dr Tom Shakespeare.

Right: Students visit the collaborative CRC booth on display during Genetech 2002 week.

Speakers and CRC-CGF representatives Prof. A .Dunn, The Hon. Dr. B. Jones, Ms R. Clark, Dr S. Lanning, Dr. John Flack, Assoc. Prof. E. Nice at the Opening Ceremony of Genetech 2002

Dr Eric Hunter speaks to CRC staff and students at the commercialisation seminar "Biotechnoology in the New Economy"

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Great Australian Science Show

Several CRC-CGF members participated in the Australian Society for Medical Research (ASMR) stand at the Great Australian Science Show (GASS) in November 2001. The event was held at the Melbourne Exhibition Centre at Southbank and those attending the stand and interacting with the public included Dr Sandra Nicholson, Leecia Angus and Ann Cornish. The stand had a model of a human torso with removable parts for the public to pull apart and rebuild. Posters were displayed and careers brochures were also made available.

Interaction with Investment Group BBY

Burdett, Buckeridge and Young Limited (BBY) is a specialist Australian Stockbroker delivering institutional and private broking along with corporate finance services, and has offices in Sydney, Melbourne, New York and London. At BBY’s invitation, Dr Doug Hilton gave two seminars about biotechnology to BBY clients and researchers as well as to members of the general investment community. The seminars, which were held in Sydney and Melbourne, each attracted approximately fifty people.

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CRC Association Annual Conference

The CRC-CGF Director, Dr John Flack, Deputy Director Dr Ian Street, Roslyn Clark and Rachel Mansfield attended this year’s CRC Association Conference. The conference and its associated satellite meetings were held over three days in Sydney, New South Wales. During the conference, Dr Flack was one of six Directors/CEOs to attend a media conference, “Benefits from Biotech R & D”. The Directors each gave a three-minute summary of the benefits resulting from their CRC research, and these were followed by questions from journalists. Dr Flack’s media statement lead to an interview with the press and a newspaper article describing the Centre’s research into the SOCS molecules.

Science Meets Parliament

Science and science education were brought to the forefront of our politicians’ minds during the Science Meets Parliament Day in August 2001 when 146 MPs met with 180 scientists. The day, organised by the Federation of Australian Science and Technological Societies (FASTS), had representatives from ten different CRCs including the CRC-CGF which was represented by Leecia Angus and Dr Doug Hilton. Doug and Leecia met with Senator Jan McLucas from Queensland, Mrs Fran Bailey, Member for McEwan, Victoria, Mr Stewart McArthur, Member for Corangamite, Victoria and Ms Leonie Short, Member for Ryan in Queensland. The four major issues discussed during Science Meets Parliament were increasing the level of business investment into R & D, addressing the shortage of science and mathematics teachers, additional funding for the university sector and improved co-ordination of the national science and technology effort.

In February, an event called ‘Biotechnology for Funds Managers’ was organised in collaboration with the Securities Institute of Australia. The audience of approximately one hundred people, the majority of whom were from the fund managers’ industry, listened to Prof. Adrienne Clarke (CRC for Bioproducts), Prof. Graham Mitchell (CRC-VT and Gene CRC) and Dr Doug Hilton (CRC-CGF) speak about investment into biotechnology. This was followed by talks from panel members Dr Amanda Caples (CRC-CGF/AMRAD), Dr David Ryan (CSL Ltd), Dr Vivien Santer (Griffith Hack) and Ms Brigette Smith (Rothschild Bioscience Unit) about biotechnology, licensing and investment in biotechnology. The panel also led discussion with the audience. The event was held at the Grand Hyatt Hotel, Melbourne, and was convened by Dr Greg Wilson from The University of Melbourne and Ms Bronwen Murdoch from the Securities Institute of Australia.

From the questionnaire data collected at ‘Biotechnology for Funds Managers’, most of the participants thought the sessions made very worthwhile contributions to their professional development, both at individual and organisational levels. A significant number of finance respondents (more than 55%) also indicated that they would be willing to consider a professional relationship with a CRC and/or an Australian biotechnology venture. The feedback received about the quality and content of the presentations was extremely positive enabling us to conclude that the seminar was a resounding success.

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Visits to the CRC-CGF

Polytechnic Tour of Amrad

A tour of Amrad for Singapore Polytechnic students was held late last year. Leecia Angus and Assoc. Prof. Ed Nice (CRC-CGF) were involved in organising this through The University of Melbourne’s Faculty of Science. The tour was part of an attachment program with the Faculty of Science that forms a component of the industrial training module of the students’ Diplomas in Singapore. Approximately 30 biotechnology and biomedical students from the school of Life Science and Chemical Technology, Ngee Ann Polytechnic Singapore, visited Amrad on 13 November and heard talks by Amrad and Cerylid representatives Dr Andrew Nash and Dr Murray Tait.

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Visiting Scientists

Prof. Stephen Withers visited the CRC-CGF in June 2002. Prof. Withers holds a joint appointment in the Departments of Chemistry & Biochemistry, University of British Columbia, Vancouver, Canada. The primary research interests of this laboratory centre upon the structures and mechanisms of enzymes, which catalyse glycoside hydrolysis and other glycosyl transfers. Prof. Withers, whose visit was hosted by the Deputy Director, Dr Ian Street, spoke on the topic “Understanding and Exploiting Glycosidases”.

 

2002/03

 

CRC-CGF Sponsored Meetings

Bioinformatics Course

The 4th Annual Introduction to Bioinformatics Course was held from 9th to 13th September 2002. The workshop examined the background, concepts and techniques for effective use of genetic, protein and biological databases. The practical sessions provided examples  and hands-on experience for exploiting these databases. The lectures and tutorials were presented by academic staff from LICR, WEHI, The Howard Florey Institute of Experimental Physiology and the University of Melbourne. There were 27 postgraduate students selected from over 40 applicants, which included 12 participants from Victoria and 12 from interstate (3 from Tasmania, 1 from Queensland, 1 from ACT, 2 from South Australia and 5 from NSW). The morning lectures held at The Howard Florey  Institute were open for all interested and were extremely well attended. Several CRC-CGF members were among the presenters, including Prof. Antony Burgess, Dr Tom Garrett, Dr Nathan Hall and Prof. Richard Simpson.

 

The Course was jointly organised by LICR, WEHI, CRC-CGF, The Howard Florey Institute and supported by BETP, Cytopia and Applied Biosystems. Dr Robert Flegg was directly involved in organising this with assistance from colleagues Drs Cassandra Thumwood and Nathan Hall.

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CRC-CGF Workshops

To assist researchers in keeping up-to-date with the latest developments in research and laboratory techniques, a number of workshops were organised by the CRC-CGF during the year:

Protein Expression Workshop

The 4th Protein Expression Workshop, hosted by the CRC-CGF and CSIRO, was held at CSIRO’s Parkville site from 1st to 2nd August 2002. The workshop covered many topics such as molecular biology, fermentation, protein purification, crystallization and structural analysis. These skills are required for the successful production of complex recombinant glycoproteins. The workshop was designed to give an overview of the integrated approach necessary for protein expression. On Day One, the requirements of crystallography and protein chemistry were first discussed along with recent developments in recombinant expression systems.

 

The presentations following this session were on the theoretical aspects of both small and large-scale cultivation of mammalian, hybridoma and insect cells, including the basic purification steps of conditioned media. On Day Two, a practical session was held to discuss equipment, media and current techniques involved in scale up and large-scale cell culture Registrants at the 4th Protein Expression Workshop, held at CSIRO.        work in all the expression systems considered. Case studies were then presented

                                                                                    and laboratories were visited to provide hands-on knowledge of the set-up and use of different production systems. On both days, sponsors had trade displays for the participants to view. A number of CRC-CGF staff gave presentations at the workshop, including Drs George Lovrecz, Tim Adams, Jose Varghese, Helene Martin, Ian Street and Louis Lu and Rachel Mansfield.

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The Chip Technology Series

A series of three lectures or workshops on chip technology was presented by LICR and the CRC-CGF during the year and organised by A. Prof. Ed Nice:

 

 - BiaCore Workshop

The first event in the series was in two phases and began with the 4th Australian Biacore Symposium held on Tuesday 22rd October at The Chiffley Hotel in Melbourne. The CRC-CGF participated in this event and provided organisational support. Dr David Myszka, from the Centre for Biomolecular Interaction Analysis, The University of Utah, Salt Lake City, USA, spoke on high resolution screening using the new BiaCore S51 technology.

Dr Myszka has made a number of significant contributions to the field of biosensor-based research, both in improving methods of experimental design as well as data analysis. Dr Kara Herlihy from Biacore Inc. in New Jersey, USA, spoke about recovery from biosensor surfaces using SPR/MS. Speakers from within Australia included Dr Rod Fiddes from AMBRI Limited in New South Wales, A. Prof. Ed Nice from CRC-CGF/LICR who also chaired the morning sessions, Dr Briony Forbes from the Department of Molecular Biosciences, the University of Adelaide, South Australia, Dr David Small, from the Department of Pathology, the University of Melbourne and Dr Mibel Aguilar from the Department of Biochemistry and Molecular Biology, Monash University. The second phase was a CRC-CGF lecture held on the following day, 23rd October. Dr David Myszka spoke on the emerging technologies in this field and scientists from several institutes in the Parkville area and the wider metropolitan region attended the workshop. Biacore provided morning tea refreshments following the lecture.

 

Biacore Workshop: A. Prof. Ed Nice (LICR)

with guest speaker Dr David Myszka

 

- BioChip Workshop

The LICR, in association with the CRC-CGF, sponsored a BioChip Workshop where Prof. Yoon-Sik Lee from the School of Chemical Engineering, Seoul National University, in Korea spoke on ‘Recent Developments of Micro Systems for Protein Extraction and Peptide Array Synthesis on a Chip’. This workshop, which was the next presentation in the continuing education series on chip technology hosted by the Centre, was held on Friday 20th December. Recent developments in micro fabrication processes and micro detection systems have driven new waves of advanced technologies in the field of Bio-MEMS (Micro Electro Mechanical Systems), especially in the field of micro systems for protein extraction and identification. Prof. Lee described how these new methods are much simpler, use fewer reagents, and are more effective in terms of both time and labour for performing sensitive binding assays.

 

- Clinical Uses of Peptide Microarrays

The Centre, together with LICR, held the final presentation in the series on Monday 17th February 2003 in which the use of peptide microarrays in the clinical setting was discussed. Prof. Kit Lam, who was also in Australia to attend the Lorne Cancer Conference, spoke on ‘Application of Combinatorial Chemistry and Chemical Microarrays to Cancer Therapeutics and Proteomics’. Prof. Lam is Professor of Medicine in the Division of Haematology/Oncology at the University of California, Davis in Sacramento. He is both an oncologist and an expert in the field of combinatorial chemistry and has developed a simple, rapid method for creating chemical libraries that can contain more than a million different peptide compounds. Prof. Lam detailed how these techniques could be used for rapid drug development and proteomics-based approaches to drug discovery.

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Interactions with the Public

CRC-CGF World Wide Web Site

The CRC-CGF maintains a web site providing information about the Centre and its contact details. Structure and research programs of the Centre, forthcoming events and education programs such as the Undergraduate Research Opportunities Program are displayed on the site. The CRC-CGF web master is Dr Nathan Hall from LICR.

Genetech 2003

 

The Biotechnology Education and Training Program (representing the 4 partnering CRCs), Melbourne Museum Victoria, The Gene Technology Access Centre (GTAC) and Gene Technology Information Service (GTIS/Biotechnology Australia) again collaborated together to present Genetech 2003 which was held on the 14th and 15th May and the 20th and 21st May. Genetech 2003 was a festival to show-case biotechnology and education initiatives in Victoria for secondary schools and to provide information to the Victorian school community about the services and resources on officer in biotechnology.

 

The first week of Genetech coincided with Education Week, during which government schools were invited to participate. The student program

began with a morning address by Dr Andrea Horvath entitled ‘50 years of DNA science – the journey so far and the journey ahead’. Students then attended four different activity stations spending 45 minutes at each. These stations were designed to provide the students with an opportunity to gain an understanding of the techniques and processes involved in working with DNA, and also to raise the awareness of the applications of biotechnology and the surrounding ethical considerations. The second week of Genetech was available to non-government schools, in particular Year 9 and 10 Victorian students and followed a similar format to the first week. At least 30 schools were represented during Genetech and over 100 teachers participated.

 

A teacher professional development afternoon session was held on Tuesday the 20th May at the Melbourne Museum. The opening address was by Dr Andrea Horvath and was followed by a keynote address by Professor Peter Doherty on ‘Fighting Infection’. A further presentation was made by the collaborating institutions to highlight the educational objectives of Genetech.

 

The City Of Melbourne, BETP and GTIS collaborated during Genetech to host a hypothetical discussion open to the general public on medical applications of biotechnology. The hypothetical ‘Will our baby win gold’ was held on the evening of 20th May 2003 at the Melbourne Town Hall. Human health applications of biotechnology have raised considerable ethical and social issues over recent years and the event was an ideal forum for the community to access information and to participate in discussions about the technology. Members of the public were able to hear from and ask questions of expert speakers about the latest advances in human health applications of biotechnology.

 

Dr Norman Swan from ABC Radio National hosted the session, as he is a well-known reputable medical reporter and media personality in addition to being medically qualified. The panel members were selected for their experience to play the role required by the script. The panel consisted of two members of the CRC-CGF, Dr Doug Hilton and Prof Ashley Dunn. Dr Hiltons' character was that of the Director of ‘Genes Are Us’, the commercialisation division of the

Above:The hypothetical ‘Will our baby win gold’ held at the Melbourne Town          fictitious ‘Sir John  the Howard Institute’,and Prof. Ashley Dunn played

Hall during Genetech week. The panel was hosted by Dr Norman Swan and             the character of the Head of this institute’s Genetic Medicine.

included two CRC-CGF members, Dr Doug Hilton and Prof. Ashley Dunn

 

The response to the hypothetical was excellent as the topic of genetics and ethics can be controversial and almost 200 people attended this event despite it being a cold and rainy night.

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Rotary Presentations

 

The Rotary ‘Biotechnology’ 2003 lecture series was funded by the BETP and the four participating CRCs. The purpose of these seminars was to inform Rotary members from industry and the finance sector of the current state of biotechnology research and engage the general community in discussions about the potential social and economic benefits arising from scientific research. Rotary brings together leaders in their field from a range of industries and professions and BETP has considered it important to bring biotechnology to people in such leadership positions. The speakers provided information about the many exciting aspects of biotechnology that are currently emerging and the advances that promise a generation of new products and enhanced production of existing products in medicine, agriculture, manufacturing and veterinary science. The CRC-CGF representatives on the organising committee were Rachel Mansfield and Dr Greg Wilson.

 

The CRC speakers and host rotary clubs were as follows: Dr Greg Wilson (BETP), The Rotary Club of Brighton; Simone Poznanski (CRC for Bioproducts), The Rotary Club of South Bank; Dr Tony Bacic (CRC for Bioproducts), The Rotary Club of Canterbury; Dr Brendan Crabb (CRC for Vaccine Technology), The Rotary Club of Melbourne; Alex Gason (PhD student, Gene CRC), The Rotary Club of Williamstown; Dr Sandra Nicholson (CRC-CGF), The Rotary Club of Richmond.

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DEST / University of Melbourne Lectureship Brochure
 

In order to publicise the role of the CRCs and the University of Melbourne in public forums organised through the Lectureship Program, a brochure has been produced. The brochure sets out the Program’s aims, explains what biotechnology is and gives a general description of CRCs. The brochure also contains some specific information about the University of Melbourne and each of the five CRCs involved in the Program. Details of the CRCs participating in this Program are given in Cooperative Linkages.

 

Careers Upgrade Fair 2002

 

The CRC-CGF participated in the University of Melbourne's Careers Upgrade Fair, an important event providing information about the options available to students and graduates with regard to postgraduate study. The event was held on the 18th of September in the Grand Buffet Hall in the University's Student Union Building. This event was open to students and graduates from universities other than the host university, and was held as part of the University of Melbourne's Postgraduate Information Week. The Fair provided a unique opportunity for students to meet with faculty and professional association representatives to learn about the programs.

 

CRC Association Annual Conference

 

The CRC-CGF Director, Dr John Flack, Deputy Director, Dr Ian Street, Roslyn Clark and Rachel Mansfield attended this year’s CRC Association Annual Conference. The conference and its associated satellite meetings were held over three days in May 2003 in Canberra, ACT. Dr John Flack presented at the CEO's Workshop and Roslyn Clark and Rachel Mansfield attended the Business Managers Workshop Education and Training Managers Workshop respectively.

 

Science Meets Parliament Day

 

Once again the Science Meets Parliament Day provided an opportunity for scientists to meet individually and corporately with politicians in Canberra. From the 12th to13th of November, 154 scientists converged on Parliament House and met with 130 MPs one-on-one  o discuss national investment in science and research generally, and specific issues of importance to the scientific community. The event, which was organised by the Federation of Australian Science and Technological Societies (FASTS), was attended by twelve CRCs on behalf of the CRC Association, as well as many other associations and societies. Dr John Flack and Roslyn Clark attended on behalf of the CRC-CGF and met with Ms Anna Burke, Member for Chisholm, Victoria, Mr Alan Griffin, Member for Bruce, Victoria and Victorian Senator Gavin Marshall.

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Visits to the CRC-CGF

 

 

Anna Burke, MP

 

Ms Anna Burke, Member for Chisholm, Victoria, and Office Manager Simon Hammersley visited the CRC-CGF on 25th February 2003. Ms Burke came at the invitation of the Director after meeting at the Science Meets Parliament day in November of 2002. The visit began with a round table discussion, attended by Prof. Suzanne Cory, Prof. Nick Nicola and Dr Margaret Brumby (all representing WEHI) and Dr John Flack and Roslyn Clark from the CRC- GF. Ms Burke was taken on a tour of the Australian Genome Research Facility (AGRF) and then met with Prof. Antony Burgess, Director of LICR. The visit concluded with afternoon tea and some short research presentations given by three WEHI scientists involved in key discoveries: Dr Doug Hilton, Dr Gabrielle Belz and Dr Louis Schofield.

 

 

Indian Education Tour, supported by DEST

As part of a national tour of Australian education and training sites sponsored by DEST, Mr Tripathi, Secretary of the Department of Secondary and Higher Education in India, visited the Centre on 14th May 2003. The main aim of the visit was to promote greater cooperation and linkages between Australian and Indian education communities. Mr Tripathi was shown a presentation prepared by Dr John Flack and Rachel Mansfield outlining the structure and organisation of the CRC-CGF and the various education and training programs in place, in particular the UROP scheme. This was followed by further discussion and a lunch held at the University of Melbourne’s University House.

 

Japanese Society for the Promotion of Science

In May 2003, the Centre was privileged to host a visit by Mrs Yuko Furukawa, Head of the International Research Cooperation Division, Japan Society for the Promotion of Science. The visit, part of a tour of some of the key biomedical centres in Victoria, was organised by the Australian Academy of Technological Sciences and Engineering and aimed to provide links that will result in further science and technology exchanges and collaborations between Japan and Australia. Mrs Furukawa, who was interested to learn more about Australia’s experience of CRC collaboration, met with Director Dr John Flack as well as Prof. Suzanne Cory, Director of WEHI, and Prof. Antony Burgess, Director of LICR.

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Send comments to crccgf@wehi.edu.au, January 2004.