| Publications |
Primary Research Papers
1997/98
1998/99
1999/2000
2000/01
2001/02
2002/03
Reviews and Book Chapters
2000/01
Media Reports, Press Releases and Articles
Following is a listing of printed media which CRC-CGF members have
contributed towards. As well, a listing of times when the CRC-CGF
has featured in the general media is provided.
Members of the CRC-CGF, at time of publishing, in bold typeface
1997/98| Adams TE, Hansen JA, Starr R, Nicola NA, Hilton DJ and Billestrup N (1998) Growth hormone preferentially induces the rapid, transient expression of SOCS-3, a novel inhibitor of cytokine receptor signalling. J Biol Chem 273:1285-1287 PubMed Link | Arber S, Barbayannis FA, Hanser H, Schneider C, Stanyon CA, Bernard O and Caroni P (1998) Regulation of actin dynamics through phosphorylation of cofilin by LIM-kinase. Nature 393:805-809 PubMed Link |
| Barnham KJ, Torres AM, Alewood D, Alewood PF, Domagala T , Nice EC and Norton RS (1998) Role of the 6-20 disulfide bridge in the structure and activity of epidermal growth factor. Protein Science 7:1738-1749 PubMed Link | Bartlett PJ, Brooker GJ, Faux CH, Dutton R, Murphy M and Kilpatrick TJ (1998) Regulation of neural stem cell differentiation in the forebrain. Immunol & Cell Biol 76:414-418 PubMed Link |
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Bernard R, Dieni S, Rees S and Bernard O (1998) Physiological and induced neuronal death are not affected in NSE-bax transgenic mice. J Neurosci Res 52:247-259 PubMed Link |
Biben C, Stanley E, Fabri L, Kotecha S, Rhinn M, Drinkwater C , Lah M, Wang CC, Nash A , Hilton D, Ang SL, Mohun T and Harvey RP (1998) Murine cerberus homologue mCer-1: a candidate anterior patterning molecule. Dev Biol 194:135-151 PubMed Link |
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Curtis DJ, Hilton DJ, Roberts B, Murray L, Nicola N and Begley CG (1997) Recombinant soluble interleukin-11 (IL-11) receptor a-chain can act as an IL-11 antagonist. Blood 90:4403-4412 PubMed Link |
Curtis D,
Robb L, Strasser A and Begley CG (1997) The CD2-scl
transgene alters the phenotype and frequency of T-lymphomas in
N-ras transgenic or p53-deficient mice. Oncogene 15:2975-2983
PubMed Link |
|
Douglas AM, Grant SL, Goss GA, Clouston DR, Sutherland RL and Begley CG (1998) Oncostatin M induces the differentiation of breast cancer cells. Int J Cancer 75:64-73 PubMed Link |
Gainsford T, Roberts AW, Kimura S, Metcalf D , Dranoff G, Mulligan RG, Begley CG, Robb L and Alexander WA (1998) Cytokine production and function in c-mpl-deficient mice: no physiological role for interleukin-3 in residual megakaryocyte and platelet production. Blood 91:2745-2752 PubMed Link |
| Grumont RJ, Rourke IJ, O'Reilly LA, Strasser A, Miyake K, Sha W and Gerondakis S (1998) B lymphocytes differentially use the Rel and nuclear factor kB1 (NF-kB1) transcription factors to regulate cell cycle progression and apoptosis in quiescent and mitogen-activated cells. J Exp Med 187:663-674 PubMed Link | Hammacher A, Richardson RT, Layton JE, Smith DK, Angus LJL, Hilton DJ, Nicola NA, Wijdenes J and Simpson RJ (1998) The immunoglobulin-like module of gp130 is required for signaling by interleukin-6, but not by leukemia inhibitory factor. J Biol Chem 273:22701-22702 PubMed Link |
| Hilton DJ, Richardson RT, Alexander WS, Viney EM, Willson TA, Sprigg NS, Starr R, Nicholson SE, Metcalf D and Nicola NA (1988) Twenty proteins containing a C-terminal SOCS box form five structural classes. Proc Natl Acad Sci USA 95:114-119 PubMed Link | Hinds MG , Maurer T, Zhang JG, Nicola NA and Norton RS (1998) Solution structure of leukaemia inhibitory factor. J Biol Chem 273:13738-13745 PubMed Link |
| Kimura S , Roberts AW, Metcalf D and Alexander WS (1998) Hematopoietic stem cell deficiencies in mice lacking c-Mpl, the receptor for thrombopoietin. Proc Natl Acad Sci USA 95:1195-1200 PubMed Link |
Koblar SA,
Turnley AM, Classon BJ, Reid KL, Ware CB, Cheema
SS, Murphy M and Bartlett PF (1998) Neural
precursor differentiation into astrocytes requires signaling through
the leukemia inhibitory factor receptor. Proc Natl Acad Sci USA
95:3178-3181
PubMed Link |
| Lackmann M, Oates A, Dottori M, Smith FM, Do C, Power M, Kravets L and Boyd AW (1998) Distinct subdomains of the EphA3 receptor mediate ligand binding and receptor dimerization. J Biol Chem 273:20228-20237 PubMed Link | Layton JE , Iaria J, Smith DK and Treutlein HR (1997) Identification of a ligand binding site on the granulocyte colony-stimulating factor receptor by molecular modeling and mutagenesis. J Biol Chem 272:29735-29741 PubMed Link |
| Marzella P, Clark G, Shepherd R, Bartlett PF, Kilpatrick TJ (1998) Synergy between TGF-b3 and NT-3 to promote the survival of spiral ganglia neurons in vitro. Neurosci Lett 240:77-80 PubMed Link | Matthews JM, Ward LD, Hammacher A, Norton RS and Simpson RJ (1997) Interaction of histidine-31 and tryptophan-34 in recombinant murine interleukin-6: Definition by NMR and effect on fluorescence properties and association behaviour. Biochem 36:6187-6196 PubMed Link |
| Metcalf D, Nicola NA and Robb L (1997) Differentiation commitment in normal hemopoiesis and leukemic transformation. J Cell Physiol 173:131-134 PubMed Link | Nice EC, Domagala T, Smyth F, Konstantopoulos N, Nerrie M , Geleick D, Catimel B and Burgess AW (2000) Applications of optical biosensors to structure-function studies in the EGF/EGF Receptor system. In: "Proceedings of the 1998 Chinese Peptide Symposium", (Hu X-Y, Wang R and Tam JP, Eds), Kluwer-escom, Dordrecht, pp238-243 |
| Robb L, Li R, Hartley L, Nandurkar HH, Köntgen F and Begley CG (1998) Infertility in female mice lacking the receptor for interleukin-11 is due to a defective uterine response to implantation. Nat Med 4:303-308 PubMed Link |
Smith DK and Treutlein HR (1998) LIF receptor-gp130 interaction investigated by homology modeling: Implications for LIF binding. Prot Science 7:886-896 PubMed LinK |
| Yao SY, Hinds MG and Norton RS (1998) Improved estimation of protein rotational correlation times from 15N relaxation measurements. J Magnet Resonance 131:347-350 PubMed Link | Walker F , Hibbs ML, Zhang H-H, Gonez LJ and Burgess AW (1998) Biochemical characterization of mutant EGF receptors expressed in the hemopoietic cell line BaF/3. Growth Factors 16:53-67 PubMed Link |
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Walker F , Kato A, Gonez J, Hibbs ML, Pouliot N, Levitzki A and Burgess AW (1998) Activation of the Ras/MAPK pathway by kinase defective epidermal growth factor receptors results in cell survival but not proliferation. Mol & Cell Biol 18:7192-7204 PubMed Link |
Zeng J, Treutlein HR and Simonson T (1998) Conformation of the Ras-binding domain of Raf studied by molecular dynamics and free energy simulations. Proteins: Struc Funct Gen 31:186-200 PubMed Link |
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Zhang JG, Zhang Y, Owczarek CM, Ward LD, Moritz RL, Simpson RJ , Yasukawa K and Nicola NA (1998) Identification and characterization of two distinct truncated forms of gp130 and a soluble form of leukaemia inhibitory factor receptor a-chain in normal human urine and plasma. J Biol Chem 273:10798-10805 PubMed Link |
Zhang Y , Owczarek CM, Layton MJ, Metcalf D, Roberts
B and Nicola NA (1997) The unusual species cross-reactivity
of the leukemia inhibitory factor receptor a-chain is determined
primarily by the immunoglobulin-like domain. J Biol Chem 272:23…
PubMed Link
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Alexander WS, Rakar S, Robb L, Farley A, Willson TA, Zhang J-G, Hartley L , Kikuchi Y, Kojima T, Nomura H, Hasegawa M, Maeda M, Fabri L, Jachno K, Nash A, Metcalf D, Nicola NA and Hilton DJ (1999) Suckling defect in mice lacking NR6, a soluble haemopoietin receptor. Curr Biol 11:605-608 PubMed Link |
Alexander WS, Starr R, Fenner JE, Scott CL, Handman E, Sprigg NS, Corbin JE, Cornish AL, Darwiche R, Owczarek CM, Kay TWH, Nicola NA, Hertzog PJ, Metcalf D and Hilton DJ (1999) SOCS-1 is a critical inhibitor of interferon g signalling and prevents the potentially fatal neonatal actions of this cytokine. Cell 98:597-608 PubMed Link |
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Basser R , To LB, Begley CG, Juttner CA, Maher DW, Szer J, Cebon J, Collins JP, Russell I, Olver I, Gill PG, Fox RM and Sheridan WP and Green MD (1999) Adjuvant treatment of high risk breast cancer using multi-cycle high-dose chemotherapy and Filgrastim-mobilized peripheral blood progenitor cells. Clin Cancer Res 1:715-721 PubMed Link |
Basser RL , To LB, Collins JP, Begley CG, Keefe D, Cebon J, Bashford J, Durrant S, Szer J, Kotasek D, Juttner C, Russell I, Maher DW, Olver I, Sherdian WP, Fox RM and Green MD (1999) Multicycle high-dose chemotherapy and Filgrastim-mobilized peripheral blood progenitor cells in women with high-risk Stage II or II breast cancer: five year follow up. J Clin Onc 17:82-92 PubMed Link |
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Cambier N, Zhang Y, Vairo G, Kosmopoulos K, Metcalf D, Nicola NA and Elefanty AG. (1999) Expression of BCR-ABL in M1 myeloid leukemia cells induces differentiation without arresting proliferation. Oncogene 18:343-352 PubMed Link |
Cole AR, Hall NE, Treutlein HR, Eddes JS, Reid GE, Mortiz RL and Simpson RJ (1999) Disulfide bond structure and N-glycosylation sites of the extracellular domain of the human interleukin-6 receptor. J Biol Chem 274:7207-7215 PubMed Link |
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Domagala T , Konstantopoulos N, Smyth F, Jorissen RN, Fabri L , Geleick D, Lax I, Schlessinger J, Sawyer W, Howlett GJ, Burgess AW and Nice EC (1999) Stoichiometry, kinetic and binding analysis of the interaction between Epidermal Growth Factor (EGF) and the extracellular domain of the EGF Receptor. Growth Factors 18:11-29 PubMed Link |
Dowsing BJ, Morrison WA, Nicola NA, Starkey GP, Bucci T and Kilpatrick TJ (1999) Leukemia inhibitory factor is an autocrine survival factor Schwann cells. J Neurochem 73:96-104 PubMed Link |
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Dutton R, Yamada T, Turnley A, Bartlett PF, and Murphy M (1999) Sonic Hedgehog promotes neuronal differentiation of murine spinal cord precursors and collaborates with neurotrophin-3 to induce islet-1. J Neurosci 19:2601-2608 PubMed Link |
Elefanty AG, Begley CG, Metcalf D, Barnett L, Köntgen F and Robb L (1998) Characterization of hematogpoietic progenitor cells that express the transcription factor SCL using a lacZ "knock-in" strategy. Proc Natl Acad Sci USA 95:11897-11902 PubMed Link |
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Halford MM , Oates AC, Hibbs ML, Wilks AF and Stacker SA (1999) Genomic structure and expression of the mouse growth factor receptor related to tyrosine kinases (Ryk). J Biol Chem 274:7379-7390 PubMed Link |
Henry BA, Goding JW, Alexander WS, Tilbrook AJ, Canny BJ, Dunshea F, Rao A, Mansell A and Clarke IJ (1999) Central administration of leptin to ovariectomixed ewes inhibits food intake without affecting the secretion of hormones from the pituitary gland; evidence for a dissociation of effects on appetite and neuroendocrine function. Endocrinology 140:1175-1182 PubMed Link |
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Hinds MG, Norton RS, Vaux DL and Day CL (1999) Solution structure of a baculoviral inhibitor of apoptosis (IAP) repeat. Nature Struct Biol 6:648-651 PubMed Link |
Lah M , Brodnicki T, Maccarone P, Nash A, Stanley E and Harvey RP (1999) Human cerberus related gene CER1 maps to chromosome 9. Genomics 55:3770-3774 PubMed Link |
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Layton JE, Shimanoto G, Osslund T, Hammacher A, Smith DK, Treutlein H and Boone T (1999) Interaction of granulocyte colony-stimulating factor (G-CSF) with its receptor: evidence that Glu19 of G-CSF interacts with Arg288 of the receptor. J Biol Chem 274:17445-17451 PubMed Link |
Losman LA, Chen XP, Hilton DJ and Rothman P (1999) Cutting edge: SOCS-1 is a potent inhibitor of IL-4 signal transduction. J Immunol 162:3770-3774 PubMed Link |
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Lock P, Casagranda F and Dunn AR (1999) Independent binding sites mediate interaction of Dok-Related protein with Ras GTPase activating protein and Nck. J Biol Chem 274:22775-22784 PubMed Link |
Marzella P, Clark G, Shepherd R, Bartlett PF and Kilpatrick TJ (1999) The neurotrophins act synergistically with LIF and members of the TGFb superfamily to promote the survival of spiral ganglia neurons in vitro. Hearing Res 138:73-80 PubMed Link |
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Matthews JM, Hammacher A, Howlett GJ and Simpson RJ (1998) Physicochemical characterization of an antagonistic human interleukin-6 dimer. Biochemistry 37: 10671-10680 PubMed Link |
Metcalf D (1998) Lineage commitment in the progeny of murine hematopoietic pre-progenitor cells: Influence of thrombopoietin and interleukin-5. Proc Natl Acad Sci USA 95:6408-6412 PubMed Link |
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Metcalf D, Alexander WS, Elefanty AG, Nicola NA, Hilton DJ, Starr R, Mifsud S and DiRago L (1999) Aberrant hematopoiesis in mice with inactivation of the gene encoding SOCS-1. Leukemia 13:926-934 PubMed Link |
Metcalf D, Mifsud S, Di Rago L, Robb L, Nicola NA and Alexander W (1998) The biological consequences of excess GM-CSF levels in transgenic mice also lacking high-affinity receptors for GM-CSF. Leukemia 12:353-362 PubMed Link |
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Metcalf D, Nicola NA, Mifsud S and Di Rago L (1999) Receptor clearance obscures the magnitude of granulocyte-macrophage colony-stimulating factor responses in mice to endotoxin or local infections. Blood 93:1579-1585 PubMed Link |
Moritz RL, Ward LD, Tu G-F, Fabri LJ, Ji H, Yasukawa K and Simpson RJ (1999) The N terminus of gp130 is critical for the formation of the high affinity interleukin-6 complex. Growth Factors 16:265-78 PubMed Link |
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Nicholson S, Willson TA, Farley A, Starr R, Zhang J-G, Alexander WS, Metcalf D, Hilton DJ and Nicola NA (1999) Mutational analysis of the SOCS proteins suggests a dual domain requirement but distinct mechanisms for inhibition of LIF and IL-6 signal transduction. EMBO J 18:375-385 PubMed Link |
Roberts MM, Swart BW, Simmons PJ, Basser RL, Begley CG and To LB (1999) Prolonged release and c-kit expression of haemopoietic precursor cells moblized by stem cell factor and granulocyte colony stimulating factor. Brit J Haematol 104:778-784 PubMed Link |
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Scott CL , Hughes DA, Cary D, Nicola NA, Begley CG and Robb L (1998) Functional analysis of mature hematopoietic cells from mice lacking the bc chain of the granulocyte-macrophage colony-stimulating factor receptor. Blood 92:4119-4127 PubMed Link |
Seymour J, Begley CG, Dirksen U, Presnill JJ, Nicola NA, Moore PE, van Asperen P, Roth B, Burdach S and Dunn AR (1998) Attenuated hematopoietic response to GM-CSF in patients with acquired pulmonary alveolar proteinosis. Blood 92:2657-2667 PubMed Link |
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Stanley E , Biben C, Kotecha S, Fabri L, Tajbakhsh S, Wang CC, Hatzistavrou T, Roberts B, Drinkwater C, Lah M, Buckingham M, Hilton D, Nash A, Mohun T and Harvey RP (1998) DAN is a secreted glycoprotein related to Xenopus cerberus. Mech Dev 77:173-184 PubMed Link |
Starr R, Metcalf D, Elefanty AG, Brysha M, Willson TA, Nicola NA, Hilton DJ and Alexander WS (1998) Liver degeneration and lymphoid deficiencies in mice lacking suppressor of cytokine signaling-1. Proc Natl Acad Sci USA 95:14395-14399 PubMed Link |
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Zeng J, Fridman M, Maruta H, Treutlein HR and Simonson T (1999) Protein-protein recognition: An experimental and computational study of the R89K mutation in Raf and its effect on Ras binding. Prot Sci 8:50-64 PubMed Link |
Zeng J and Treutlein HR (1999) A method for computational combinatorial peptide design of inhibitors of Ras. Prot Eng 12:457-468 PubMed Link |
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Zeng J, Treutlein HR and Simonson T (1999) Molecular dynamics simulations of the Ras: Raf and Rap:Raf complexes. Proteins: Struct Funct Gen 35:89-100 PubMed Link |
Zhang J-G, Farley A, Nicholson S, Willson TA, Zugaro L, Simpson RJ, Moritz RL, Cary D, Richardson R, Hausmann G, Kile B, Kent SB, Alexander WS, Metcalf D, Hilton DJ, Nicola NA and Baca M (1999) The conserved SOCS box motif in suppressors of cytokine sugnaling binds to elongins B and C and may couple bound proteins to proteasomal degradation. Proc Natl Acad Sci USA 96:2071-2076 PubMed Link |
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Zhang Y, Willson T, Metcalf D, Cary D, Hilton DJ, Clark R and Nicola NA (1998) The box-1 region of the leukemia inhibitory factor receptor a-chain cytoplasmic domain is sufficient for hemopoietic cell proliferation and differentiation. J Biol Chem 273:34370-34383 PubMed Link |
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Alexander WS, Starr R, Metcalf D, Nicholson SE, Farley A, Elefanty AG, Brysha M, Kile BT, Richardson R, Baca M, Zhang J-G, Willson TA, Viney EM, Sprigg NS, Rakar S, Corbin J, Mifsud S, DiRago L, Cary D, Nicola NA and Hilton DJ (1999) Suppressors of cytokine signalling (SOCS): negative regulators of signal transduction. J Leuk Biol 66:588-592 PubMed Link |
Curtis DJ, Metcalf D, Alexander B, Begley CG (2000) Leukemic cells from murine myeloid leukemia display an intrinsic ability for autonomous proliferation. Exp Hematol 28:36-45 PubMed Link |
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Davey HW, McLachlan MJ, Wilkins RJ, Hilton DJ, Adams TE (1999) STAT5b mediates the GH-induced expression of SOCS-2 and SOCS-3 mRNA in the liver. Mol Cell Endocrinol 158:111-116 PubMed Link |
Day CL, Dupont C, Lackmann M, Vaux DL and Hinds MG (1999) Solution structure and mutagenesis of the caspase recruitment domain (CARD) from Apaf-1. Cell Death Differ. 6:1125-1132 PubMed Link |
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Elefanty A, Begley C, Hartley L, Papaevangeliou B, Robb L (1999) SCL expression in the mouse embryo detected with a targeted lacZ reporter gene demonstrates its localization to hematopoietic, vascular and neural tissues. Blood 94:3754-3763 PubMed Link |
Emanuelli B, Peraldi P, Filloux C, Sawkn-Verheller D, Hilton DJ, Van Obberghen E (2000) SOCS-3 is an insulin-induced negative regulator of insulin signaling. J Biol Chem 275:15985-15991 PubMed Link |
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Gainsford T, Nandurkar H, Metcalf D, Robb L, Begley CG, Alexander WS (2000) The residual megakaryocyte and platelet production in c-mpl-deficient mice is not dependent on the actions of interleukin-6, interleukin-11, or leukemia inhibitory factor. Blood 95:528-534 PubMed Link |
Halford MM, Armes J, Adams MT, Buchert M, Meskenaite V, Grail D, Hibbs ML, Wilks AF, Farlie PG, Newgreen DF, Hovens CM, and Stacker SA (2000) RYK-deficient mice exhibit craniofacial defects associated with perturbed Eph receptor crosstalk. Nature Genetics 25:414-418 PubMed Link |
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Hansen JA, Lindberg K, Hilton DJ, Nielsen JH, Billestrup N (1999) Mechanism of inhibition of growth hormone receptor signalling by suppressor of cytokine signalling proteins. Mol Endocrinol 13:1832-1843 PubMed Link |
Jorissen RN, Epa VC, Treutlein HR, Garrett TPJ, Ward CW and Burgess AW (2000) Characterization of a comparative model of the extracellular domain of the epidermal growth factor receptor. Protein Science 9:310-324 PubMed Link |
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Metcalf D, Di Rago L, Mifsud S, Hartley L, Alexander WS (2000) The development of fatal myocarditis in mice heterozygous for INFg and lacking the SOCS-1 gene. Proc Natl Acad Sci U S A 97:9174-9179 PubMed Link |
Metcalf D, Greenhalgh CJ, Viney E, Willson TA, Starr R, Nicola NA, Hilton DJ and Alexander WS (2000) Gigantism in mice lacking suppressor of cytokine signalling-2. Nature 405:1069-1073 PubMed Link |
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Nicholson SE, De Souza D, Fabri LJ, Corbin J, Willson TA, Zhang J-G, Silva A, Asimakis M, Farley A, Nash AD, Metcalf D, Hilton DJ, Nicola NA and Baca M (2000) Suppressor of cytokine signaling-3 preferentially binds to the SHP-2 binding site on the shared cytokine receptor subunit gp130. Proc Natl Acad Sci USA 97:6493-6498 PubMed Link |
Novak U, Marks D, Nicholson SE, Hilton D, Paradiso L (1999) Differential ability of SOCS proteins to regulate IL-6 and CSF-1 induced macrophage differentiation. Growth Factors 16:305-314 PubMed Link |
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Polizzotto MN, Bartlett PF and Turnley AM (2000) Expression of Suppressor of Cytokine Signalling" (SOCS) genes in the developing and adult mouse nervous system. J Comp Neurol 423:348-358 PubMed Link |
Schneider S, Buchert M, Georgiev O, Catimel B, Halford M, Stacker SA, Baechi T, Moelling K and Hovens CM (1999) Mutagenesis and selection of PDZ domains that bind new protein targets. Nature Biotechnol 17:170-175 PubMed Link |
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Scott CL, Robb L, Mansfield R, Alexander WS and Begley CG (2000) GM-CSF is not responsible for residual thrombopoiesis in mpl null mice. J. Exp. Hematol. 28:1001-1007 PubMed Link |
Scott CL, Robb L, Papaevangeliou B, Mansfield R, Nicola NA and Begley CG (2000) Reassessment of interactions between hematopoietic receptors using bc and bIL-3 null cells: no evidence for functional interactions with receptors for EPO, G-CSF or SCF: a Brief Report. Blood 96:1588-1590 PubMed Link |
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Siewert E, Muller-Esterl W, Starr R, Heinrich PC, Schaper F (1999) Different protein turnover of interleukin-6-type cytokine signalling components. Eur J Biochem 265:251-257 PubMed Link |
Stacker SA, Runting AS, Caesar C, Vitali A, Lackmann M, Chang J, Ward L and Wilks AF (2000) The 3T3-L1 fibroblast to adipocyte conversion is accompanied by increased expression of angiopoietin-1, a ligand for tie2. Growth Factors 18:177-191 PubMed Link |
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Stanley EG, Biben C, Allison J, Hartley L, Wicks IP, Campbell IK, McKinley M, Barnett L, Köntgen F, Robb L, Harvey RP (2000) Targeted insertion of a lacZ reporter gene into the mouse Cer1 locus reveals complex and dynamic expression during embryogenesis. Genesis 26:259-264 PubMed Link |
Yao S, Smith DK, Hinds MG, Zhang J-G, Nicola NA and Norton RS
(2000) Backbone dynamics measurements on leukemia inhibitory factor,
a rigid four-helical bundle cytokine. |
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Bullen DVR, Darwiche R, Metcalf D, Handman E and
Alexander WS (2001) Neutralisation of interferon-gamma in
neonatal SOCS1-/- mice prevents fatty degeneration of the liver
but not subsequent fatal inflammatory disease. Immunol 104:92-98
PubMed Link
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Brysha M, Zhang J-G, Bertolino P, Corbin JE , Alexander WS, Nicola NA, Hilton DJ and Starr R (2001) Suppressor of cytokine signaling-1 attenuates the duration of interferon gamma signal transduction in vitro and in vivo. J Biol Chem 276:22086-22089 PubMed Link |
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Curtis DJ, Jane SM, Hilton DJ, Dougherty L,
Bodine DM and Begley CG (2000) Adaptor protein SKAP55R is associated
with myeloid differentiation and growth arrest. Exp Hematol 28:1250-1259
PubMed Link
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Dimitriadis E, Salamonsen LA, and Robb L (2000) Expression
of IL-11 during the menstrual cycle: coincidence with stromal decidualization
and relationships to leukemia inhibtory factor and prolactin. Mol
Hum Reprod 6:907-914
PubMed Link
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Elleman TC, Domagala T, McKern NM, Nerrie M, Lonnqvist
B, Adams TE, Lewis J, Lovrecz GO, Hoyne PA, Richards KM,
Howlett GJ, Rothacker J , Jorissen RN, Lou M
, Garrett TP, Burgess AW, Nice EC and Ward CW (2001)
Identification of a determinant of epidermal growth factor receptor
ligand-binding specificity using a truncated, high-affinity for
m of the ectodomain. Biochemistry 40:8930-8939
PubMed Link
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Ernst M, Inglese M, Waring P, Campbell IK, Bao S, Clay FJ,
Alexander WS, Wick IP, Tarlinton DM, Novak U, Heath JK
and Dunn AR (2001) Defective gp130-mediated STAT signaling
results in degenerative joint disease, gastrointestinal ulceration
and failure of uterine implantation. J Exp Med (in press)
PubMed Link
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Faux CH, Turnley AM, Epa R, Cappai R, Bartlett PF (2001) Interactions
between fibroblast growth factors and notch regulate neuronal differentiation.
J Neurosci 21:5587-5596
PubMed Link
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Gillespie LN, Clark GM, Bartlett PF, Marzella PL (2001)
LIF is more potent than BDNF in promoting neurite outgrowth of mammalian
auditory neurons in vitro. Neuroreport 12:275-279
PubMed Link |
| Halford MM, Armes J, Adams MT, Buchert M, Meskenaite V, Grail D, Hibbs ML , Wilks AF, Farlie PG, Newgreen DF, Hovens CM, and Stacker SA (2000) RYK-deficient mice exhibit craniofacial defects associated with perturbed Eph receptor crosstalk. Nature Genetics 25:414-418 PubMed Link | Hammacher A, Wijdenes J, Hilton DJ, Nicola NA, Simpson RJ and Layton JE (2000) Ligand-specific utilization of the extracellular membrane-proximal regions of the gp130-related signalling receptors. Biochem J 345:25-32 PubMed Link |
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Harder KW, Parsons LM, Armes J, Evans N, Kountouri N, Clark
R, Quilici C, Grail D, Hodgson GS, Dunn AR, and Hibbs ML
(2001) Gain- and loss-of-function Lyn mutant mice define a critical
inhibitory role for Lyn in the myeloid lineage. Immunity (Immunity
15:603-15)
PubMed Link
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Kile BT , Metcalf D, Mifsud S, DiRago L, Nicola NA, Hilton
D and Alexander WS (2001) Functional analysis of Asb-1
using genetic modification in mice. Mol Cell Biol 21:6189-97
PubMed Link
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Kile BT, Viney EM, Willson TA, Brodnicki TC, Cancilla MR,
Herlihy AS, Croker BA, Baca M, Nicola NA, Hilton DJ
and Alexander WS (2000) Cloning and characterisation of
the genes encoding the ankyrin repeat and SOCS box-containing proteins
Asb-1, Asb-2, Asb-3 and Asb-4. Gene 258:31-41
PubMed Link
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Lindeman GJ, Wittlin S, Lada H, Santamaria M, Zhang J-G, Starr
R, Hilton DJ , Ormandy CJ, Alexander WS and Visvader
J (2001) SOCS1 deficiency results in accelerated mammary gland development
and rescues lactation in prolactin receptor-deficient mice. Genes
Dev 15:1631-1636
PubMed Link
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Li R, Hartley L and Robb L (2001) Cloning of rat interleukin-11
and interleukin-11 receptor alpha chain and analysis of their expression
in rat uterus in the peri-implantation period. Reproduction 122:593-600
PubMed Link
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Matthews JM, Norton RS, Hammacher A and Simpson RJ
(2000) The single mutation Phe173ÕAla induces a molten
globule-like state in murine interleukin-6. Biochemistry
39:942-1950
PubMed Link
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Moritz RL, Hall NE, Connolly LM and Simpson RJ (2001)
Determination of the disulfide structure and N-glycosylation sites
of the extracellular domain of the human signal transducer gp130.
J Biol Chem 276:8244-8253
PubMed Link
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Peraldi P, Filloux C, Emaneulli B, Hilton DJ and Van Obberghen
E (2001) Insulin induces suppressor of cytokine signaling-3 tyrosine
phosphorylation through janus-activated kinase. J Biol Chem 276:24614-24620
PubMed Link
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Polizzotto MN, Bartlett PF and Turnley AM (2000) Expression
of Suppressor of Cytokine Signalling (SOCS) genes in the developing
and adult mouse nervous system. J Comp Neurol 423:348-358
PubMed Link
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Pouliot N, Nice EC and Burgess AW (2001) Laminin-10
mediates basal and EGF-stimulated motility of human colon carcinoma
cells via alpha(3)beta(1) and alpha(6)beta(4) integrins. Exp Cell
Res 266:1-10
PubMed Link
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Quek LS, Pasquet JM, Hers I, Cornall R, Knight G, Barnes M,
Hibbs ML, Dunn AR, Lowell CA, and Watson SP (2000) Fyn
and Lyn phosphorylate the Fc receptor gamma chain downstream of
glycoprotein VI in murine platelets, and Lyn regulates a novel feedback
pathway. Blood 96:246-4253
PubMed Link
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Roberts AW, Robb L, Rakar S, Hartley L
, Cluse L, Nicola NA, Metcalf D,
Hilton DJ and Alexander WS (2001) Placental defects
and embryonic lethality in mice lacking suppressor of cytokine signaling
3. Proc Natl Acad Sci (USA) 98:9324-9
PubMed Link
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Ryan PJ , Willson T, Alexander WS, DiRago
L , Mifsud S and Metcalf D (2001) The multi-organ
origin of interleukin-5 in the mouse. Leukemia 15:1248-55
PubMed Link
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Salamonsen LA, Nie G, Dimitriadis E, Robb L and Findlay
JK (2001) Genes involved in implantation. Reprod Fertil Dev 13:41-49
PubMed Link
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Scott CL, Robb L, Mansfield R, Alexander
WS and Begley CG (2000) GM-CSF is not responsible
for residual thrombopoiesis in mpl null mice. J Exp Hematol 28:1001-1007
PubMed Link
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Scott CL, Robb L, Nandurkar H, Mansfield R,
Alexander WS and Begley CG (2001) Thrombopoietin
signalling is required for in vivo expansion of IL-11-responsive hematopoietic
progenitor cells in the steady state. Exp Hematol 29:138-145
PubMed Link
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Scott CL, Robb L, Papaevangeliou B, Mansfield
R, Nicola NA and Begley CG (2000) Reassessment
of interactions between hematopoietic receptors using bc and bIL-3
null cells: no evidence for functional interactions with receptors
for EPO, G-CSF or SCF: a Brief Report. Blood 96:1588-90
PubMed Link
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Silke J, Ekert PG, Day CL, Hawkins CJ, Baca M,
Chew J, Pakusch M, Verhagen AM and Vaux DL (2001) Direct
inhibition of caspase 3 is dispensable for the anti-apoptotic activity
of XIAP. EMBO J 20:3114-3123
PubMed Link
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Smith BJ, Branson K and Schuurmann G (2001) Gaussian
Theory predictions of proton transfer tp phenol and 3-chlorophenol:
resolution of an apparent difficulty. Chem Phys Lett 342:402
ScienceDirect Link
|
Stacker SA, Runting AS, Caesar C, Vitali A, Lackmann M, Chang
J, Ward L, Wilks AF (2000) The 3T3-L1 fibroblast to adipocyte conversion
is accompanied by increaed expression of angiopoietin-1, a ligand
for tie2. Growth Factors 18:177-191
PubMed Link
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Zeng J , Nheu T, Zorzet A, Catimel B, Nice E
, Maruta H, Burgess AW and Treutlein H (2001) Design
of inhibitors of Ras-Raf interaction using computational combinatorial
algorithm. Protein Eng 14:39-45
PubMed Link
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Butzkueven H, Zhang JG, Soilu-Hanninen M, Hochrein H, Chionh F, Shipham KA, Emery B, Turnley AM, Petratos S, Ernst M, Bartlett PF, Kilpatrick TJ (2002) LIF receptor signaling limits immune-mediated demyelination by enhancing oligodendrocyte survival. Nature Medicine 8(6):613-9 PubMed Link |
Carpinelli MR, Wicks IP, Sims NA, O'Donnell K, Hanzinikolas K, Burt R, Foote SJ, Bahlo M, Alexander WS, Hilton DJ (2002) An ethyl-nitrosourea-induced point mutation in phex causes exon skipping, x-linked hypophosphatemia, and rickets. Am J Pathol. 161(5):1925-33 PubMed Link |
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De Souza D, Fabri
LJ, Nash A, Hilton DJ, Nicola NA, Baca M (2002) SH2 domains from suppressor
of cytokine signaling-3 and protein tyrosine phosphatase SHP-2 have similar
binding specificities. Biochemistry 41(29):9229-36 PubMed
Link |
Dimitriadis
E, Robb L, Salamonsen LA (2002) Interleukin 11 advances progesterone-induced decidualization of human endometrial stromal cells. Mol Hum Reprod. 8(7):636-43 PubMed Link |
|
Emanuelli B, Peraldi
P, Filloux C, Chavey C, Freidinger K, Hilton DJ, Hotamisligil GS,
Van Obberghen E (2001) SOCS-3 inhibits insulin signaling and is up-regulated
in response to tumor necrosis factor-alpha in the adipose tissue of obese
mice. J Biol Chem. 276(51):47944-9 PubMed
Link |
Ernst M,
Inglese M, Waring P, Campbell IK, Bao S, Clay FJ, Alexander WS, Wicks
IP, Tarlinton DM, Novak U, Heath JK, Dunn AR (2001) Constitutive
activation of the SRC family kinase Hck results in spontaneous pulmonary
inflammation and an enhanced innate immune response. J Exp Med 196(5):589-604.
PubMed
Link |
|
Fairlie WD, Uboldi
AD, De Souza DP, Hemmings GJ, Nicola NA, Baca M (2002) A fusion protein
system for the recombinant production of short disulfide-containing peptides. |
Flores-Morales A, Fernandez L, Rico-Bautista E, Umana A, Negrin C, Zhang JG, Norstedt G (2001) Endoplasmic reticulum stress prolongs GH-induced Janus kinase (JAK2)/signal transducer and activator of transcription (STAT5) signaling pathway. Mol Endocrinol. 15(9):1471-83 PubMed Link |
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Garrett TP, McKern
NM, Lou M, Elleman TC, Adams TE, Lovrecz GO, Zhu HJ, Walker F,
Frenkel MJ, Hoyne PA, Jorissen RN, Nice EC, Burgess AW, Ward CW (2001)
Crystal structure of a truncated epidermal growth factor receptor extracellular
domain bound to transforming growth factor alpha. |
Greenhalgh
CJ, Bertolino P, Asa SL, Metcalf D, Corbin JE, Adams
TE, Davey HW, Nicola NA, Hilton DJ, Alexander WS (2002)
Growth enhancement in suppressor of cytokine signaling 2 (SOCS-2)-deficient
mice is dependent on signal transducer and activator of transcription 5b
(STAT5b). Mol Endocrinol. 2002 Jun;16(6):1394-406 PubMed
Link |
|
Johns TG, Stockert E, Ritter G, Jungbluth AA, Huang HJ, Cavenee WK, Smyth FE, Hall CM, Watson N, Nice EC, Gullick WJ, Old LJ, Burgess AW, Scott AM (2002) Novel monoclonal antibody specific for the de2-7 epidermal growth factor receptor (EGFR) that also recognizes the EGFR expressed in cells containing amplification of the EGFR gene. Int J Cancer. 2002 Mar 20;98(3):398-408 PubMed Link |
Kile BT, Metcalf D, Mifsud S, DiRago L, Nicola NA, Hilton DJ, Alexander WS (2001) Functional analysis of Asb-1 using genetic modification in mice. Mol Cell Biol. 21(18):6189-97 PubMed Link |
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Kilpatrick TJ,
Phan S, Reardon K, Lopes EC, Cheema SS (2001) Leukaemia inhibitory factor
abrogates Paclitaxel-induced axonal atrophy in the Wistar rat. |
Krebs
DL, Uren RT, Metcalf D, Rakar S, Zhang JG, Starr R, De Souza DP, Hanzinikolas
K, Eyles J, Connolly LM, Simpson RJ, Nicola NA, Nicholson
SE, Baca M, Hilton DJ, Alexander WS (2002) SOCS-6 binds to insulin receptor
substrate 4, and mice lacking the SOCS-6 gene exhibit mild growth retardation. Mol Cell Biol. 22(13):4567-78 PubMed Link |
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Metcalf D, Alexander WS, Ryan PJ, Mifsud S, Di Rago L (2001) Production of colony-stimulating factors and IL-5 by organs from three types of mice with inflammatory disease due to loss of the suppressor of cytokine signaling-1. J Immunol. 167(8):4661-7 PubMed Link |
Metcalf D, Mifsud S, Di Rago L, Nicola NA, Hilton DJ, Alexander WS (2002) Polycystic kidneys and chronic inflammatory lesions are the delayed consequences of loss of the suppressor of cytokine signaling-1 (SOCS-1). Proc Natl Acad Sci U S A. 99(2):943-8 PubMed Link |
|
Nice EC, Domagala
T, Fabri L, Nerriea M, Walker F, Jorissen RN, Burgess AW, Cui DF,
Zhang YS (2002) Rapid microscale enzymic semisynthesis of epidermal growth
factor (EGF) analogues. |
Richardson RT, Starr R, Angus LJ, Hilton DJ (2002) A somatic cell genetic system for dissecting hemopoietic cytokine signal transduction. J Biol Chem. 277(28):25624-30 PubMed Link |
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Roberts AW, Robb
L, Rakar S, Hartley L, Cluse L, Nicola NA, Metcalf D, Hilton DJ, Alexander
WS (2001) Placental defects and embryonic lethality in mice lacking
suppressor of cytokine signaling 3. Proc Natl Acad Sci U S A. 98(16):9324-9
PubMed
Link |
Tam SP, Lau P, Djiane J, Hilton DJ, Waters MJ (2001) Tissue-specific induction of SOCS gene expression by PRL. Endocrinology. 142(11):5015-26 PubMed Link |
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Tran TT, Burgess AW, Treutlein H, Perich J (2001) Synthesis, X-ray crystallographic structures of thio substituted N-acetyl N'-methylamide alanine and evaluation of sp sulfur parameters of the CFF91 force field. J Pept Res. 58(1):67-78 PubMed Link |
Tran TT,
Zeng J, Treutlein H, Burgess AW (2002) Effects of thioamide
substitutions on the conformation and stability of alpha- and 3(10)-helices. J Am Chem Soc. 124(18):5222-30 PubMed Link |
| Turnley AM, Starr R, Bartlett PF (2002) Failure of sensory neurons to express class I MHC is due to differential SOCS1 expression. J Neuroimmunol. 123(1-2):35-40 PubMed Link | Turnley
AM, Starr R, Bartlett PF (2001) SOCS1 regulates interferon-gamma mediated
sensory neuron survival. Neuroreport. 12(16):3443-5 PubMed Link |
| Ungureanu D, Saharinen P, Junttila I, Hilton DJ, Silvennoinen O (2002) Regulation of Jak2 through the ubiquitin-proteasome pathway involves phosphorylation of Jak2 on Y1007 and interaction with SOCS-1. Mol Cell Biol. 22(10):3316-26 PubMed Link |
Ward CW and Garrett TPJ (2001) The relationship between the L1 and L2 domains of the insulin and epidermal growth factor receptors to leucine-rich repeat modules. BMC Bioinformatics 2:4 (http://www.biomedcentral.com/1471-2105/2/4) |
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Zhang JG, Metcalf D, Rakar S, Asimakis M, Greenhalgh CJ, Willson TA, Starr R, Nicholson SE, Carter W, Alexander WS, Hilton DJ, Nicola NA (2001) The SOCS box of suppressor of cytokine signaling-1 is important for inhibition of cytokine action in vivo. Proc Natl Acad Sci U S A. 98(23):13261-5 PubMed Link |
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Bullen DVR, Baldwin TM, Curtis JM, Alexander WS and Handman E (2003) Persistence of Lesions in Suppressor of Cytokine Signaling-1-Deficient Mice Infected with Leishmania major. J Immunol 170:4267-4272 PubMed Link |
Bullen DVR, Hansen DS, Siomos MV, Schofield L, Alexander WS and Handman E (2003) The lack of suppressor of cytokine signalling-1 (SOCS1) protects mice from the development of cerebral malarias caused by Plasmodium bergei ANKA. Parasite Immunol 25:113-8. PubMed Link |
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Carpinelli MR, Wicks IP, Sims NA, O’Donnell K, Hanzinikolas K, Burt R, Foote SJ, Bahlo M, Alexander WS and Hilton DJ (2002) An ethylnitrosourea- induced point mutation in phex causes exon skipping, x-linked hypophosphatemia, and Rickets. Am J of Path 161:1925-1933 PubMed Link |
Chong MM, Cornish AL, Darwiche R, Stanley EG, Purton JF, Godfrey DI, Hilton DJ, Starr R, AlexanderWS , Kay TW (2003) Suppressor of cytokine signaling-1is a critical regulator of interleukin-7-dependent CD8+ T cell differentiation. Immunity 18:475-487 PubMed Link |
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Cornish AL, Chong MW, Davey GM, Darwiche R, Nicola NA, Hilton DJ, Kay TW, Starr R and AlexanderWS (2003) Suppressor of cytokine signaling-1regulates signalling in response to interleukin-2 and other gc-dependent cytokines in peripheral T cells. J Biol Chem 278:22755-22761 PubMed Link |
Cornish AL, Davey GM, Metcalf D, Purton JF, CorbinJE, Greenhalgh CJ , Darwiche R, Wu L, Nicola NA,Godfrey DI, Heath WR, Hilton DJ, Alexander WS and Starr R (2003) Suppressor of cytokine signaling-1 has IFN-gamma-independent actions in T cell homeostasis. J Immunol 170:878-886 PubMed Link |
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Croker BA, Krebs DL, Zhang JG, Wormald S, Willson TA, Stanley EG, Robb L, Greenhalgh CJ, Forster I, Clausen BE, Nicola NA, Metcalf D, HiltonDJ, Roberts AW and Alexander WS (2003) SOCS3negatively regulates IL-6 signalling in vivo. Nature Immunol 4:540-545 PubMed Link |
De Souza D, Fabri LJ, Nash AD, Hilton DJ, Nicola NA and Baca M (2002) SH2 domains from suppressor of cytokine signaling-3 and protein tyrosine phosphatase SHP-2 have similar binding specificities. Biochem 41:9229-9236 PubMed Link |
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Dimitriadis E, Robb L, Liu Y-X, Enders AC, Martin H, Stoikos C, Wallace E and Salamonsen LA (2003) IL-11 and IL-11R alpha immunolocalisation at primate implantation sites supports a role for IL-11 in placentation and fetal development. Reprod Biol and Endocrin 1:34 PubMed Link |
Dimitriadis E, Robb L, Salamonsen LA (2002) Interleukin 11 advances progesterone-induced decidualization of human endometrial stromal cells. Mol Hum Reprod 8:636-43 PubMed Link |
|
Egan PJ, Lawlor KE, Alexander WS and Wicks IP (2003) Suppressor of cytokine signaling-1 regulates acute inflammatory arthritis and T cell activation. J Clin Invest 111:915-924 PubMed Link |
Eyles JL, Metcalf D, Grusby MJ, Hilton DJ and StarrR (2002) Negative regulation of interleukin-12signalling by suppressor of cytokines signalling-1. J Biol Chem 277:43735-43740 PubMed Link |
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Fairlie WD, De Souza D, Nicola NA and Baca M (2003) Negative regulation of gp130 signalling mediated through tyrosine-757 is not dependent on the recruitment of SHP2. Biochem J 372:495-502 PubMed Link |
Fairlie WD, Uboldi AD, DeSouza DP, Hemmings GJ, Nicola NA and Baca M (2002) A fusion protein system for the recombinant production of short disulfide containing peptides. Prot Express Purif 26:171-178 PubMed Link |
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Garrett TPJ, McKern NM, Lou M, Elleman TC, Adams TE, Lovrecz GO, Kofler M, Jorissen RN, NiceEC, Burgess AW and Ward CW (2003) The crystalstructure of a truncated ErbB2 ectodomain reveals an active conformation, poised to interact with other ErbB receptors. Molecular Cell 11:495-505 PubMed Link |
Greenhalgh CJ, Metcalf D, Thaus AL, Corbin JE, Uren R, Morgan PO, Fabri LJ, Zhang J-G, Martin HM, Willson TA, Billestrup N, Nicola NA, Baca M,Alexander WS and Hilton DJ (2002) Biologicalevidence that SOCS-2 can act either as an enhancer or suppressor of growth hormone signalling. J Biol Chem 277:40181-40184 PubMed Link |
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Gunawardana DH, Basser RL, Davis ID, Cebon J, Mitchell P, Underhill C, Kilpatrick TJ, Reardon K, Green MD, Bardy P, Amor P, Crump D, Ng S, Nation RL, Begley CG. (2003) A phase I study of recombinant human leukemia inhibitory factor in patients with advanced cancer. Clin Cancer Res 6:2056-65. PubMed Link |
Jenkins BJ, Quilici C, Roberts AW, Grail D, Dunn AR and Ernst M (2002) Hematopoietic abnormalities in mice deficient in gp130-mediated STAT signalling. Exp Hematol 30:1248-1256 PubMed Link |
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Jorissen RN, Treutlein HR, Epa VC and Burgess AW (2002) Modelling the epidermal growth factor – epidermal growth factor receptor 12 domain interaction: implications for the ligand binding process. J Biol Struct Dyn 19:961-972 PubMed Link |
Jorissen RN, Walker F, Pouliot N, Garrett TPJ, WardCW and Burgess AW (2003) Epidermal GrowthFactor Receptor: Mechanisms of Activation and Signalling. Experimental Cell Research 284:31-53 PubMed Link |
|
Metcalf D, Di Rago L and Mifsud S (2003) Crowding dependent production of colony-stimulating factors by cultured syngeneic or allogeneic hematopoietic cells. Proc Natl Acad Sci (USA) 100:1244-1249 PubMed Link |
Metcalf D, Di Rago L and Mifsud S (2002) Synergistic and inhibitory interactions in the in vitro control of murine megakaryocyte colony formation. Stem Cells 20:552-560 PubMed Link |
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Metcalf D, Mifsud S and Di Rago L (2002) Stem cell factor can stimulate the formation of eosinophils by two types of murine eosinophil progenitor cells. Stem Cells 20:460-469 PubMed Link |
Metcalf D, Mifsud S, Di Rago L and Alexander WS (2003) The lethal effects of transplantation of SOCS-1-/- bone marrow cells into irradiated adult syngeneic recipients. Proc Natl Acad Sci (USA) (in press) PubMed Link |
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Nice EC, Domagala T, Fabri L, Nerrie M, Walker F, Jorissen RN, Burgess AW, Cui D-F and Zhang Y-S (2002) Rapid microscale enzymic semisynthesis of epidermal growth factor (EGF) analogues. Growth Factors 20:71-80 PubMed Link |
Richardson RT, Starr R, Angus LJ and Hilton DJ (2002) A somatic cell genetic system for dissecting hemopoietic cytokine signal transduction. J Biol Chem 277:25624-25630 PubMed Link |
|
Sarna MK, Ingley E, Busfield SJ, Cull VS, Lepere W, McCarthy DJ, Wright MJ, Palmer GA, Chappell D, Sayer MS, Alexander WS, Hilton DJ, Starr R, Watowich SS, Bittorf T, Klinken SP and Tilbrook PA (2003) Differential regulation of SOCS genes in normal and transformed erythroid cells. Oncogene 22:3221-3230 PubMed Link |
Varghese JN, Mortiz RL, Lou M-Z, Van Donkelaar A, Ji H, Ivancic N, Branson KM, Hall NE and SimpsonRJ (2002) Structure of the extracellular domains ofthe human interleukin-6 receptor alpha-chain. Proc Natl Acad Sci (USA) 99:15959-15964 PubMed Link |
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Wade JD, Domagala T, Rothacker J, Catimel B and Nice E (2002) Use of thiazolidine-mediated ligation for site specific biotinylation of mouse EGF for biosensor immobilization. LIPS 8:211-220 |
Zhu H-J, Iaria J, Orchard S, Walker F and BurgessAW (2003) Epidermal Growth Factor Receptor:association of extracellular domain negatively regulates intracellular kinase activation in the absence of ligand. Growth Factors 21:15-30 PubMed Link |
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Baca M and Zhang J (2003) In: ‘Proteins and Proteomics: A Laboratory Manual’ (Simpson RJ, Ed) Cold Spring Harbor Laboratory Press, Cold Spring Harbor, New York. |
Burgess AW (2002) Tyr kinase inhibitors as potential anticancer agents: EGFR receptor and ABL kinases. In: ‘Tumour-supressing viruses, genes, and drugs: innovative cancer therapy approaches’ (Maruta H, Ed) Academic Press, San Diego, pp341-359 |
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Burgess AW (2003) Growth Factors. In: ‘Encyclopedia of Molecular Biology and Molecule Medicine’ (Meyers RA, Ed), Weinham (Germany), New York: VCH |
Burgess AW (2003) Epidermal Growth Factors. In: ‘Encyclopedia of Hormones’ (Henry H and Norman A, Eds), Academic Press |
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Catimel B, Rothacker J and Nice E (2002) Biosensors and Proteomics. Today’s Life Science 14:24-30 |
Croker B and Nicola NA (2003) Intracellular Signaling. In: ‘Hematopoietic Growth Factors in Oncology: Basic Science and Clinical Therapeutics’ (Morstyn G, Foote M and Lieschke G, Eds) Humana Press (in press.) |
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Eyles JL and Hilton DJ (2003) Negative regulation of the JAK/STAT signaling pathway. In: ‘Handbook of Cell Signaling’, Volume 1 (Bradshaw RA and Dennis EA, Eds) Academic Press (in press) |
Forrai A and Robb L (2003) The hemangioblast – between blood and vessels. Cell Cycle 2:86-90 PubMed Link |
|
Greenhalgh CJ, Miller ME, Hilton DJ and Lund PK (2002) Suppressors of cytokine signalling: relevance to gastrointestinal function and disease. Gastroenterology 123:2064-2081 |
Greig K and Hilton DJ (2003) Mouse Mutagenesis: Towards an Understanding of Human Gene Function. Today’s Life Science 15:38-41 |
|
Krebs DL and Hilton DJ (2003) A new role for SOCS in insulin action. Suppressor of cytokine signalling. Science’s STKE (169):PE6 [electronic resource] |
Nice E and Catimel B (2003) Affinity based biosensors, microarrays and proteomics. In: ‘Proteome Analysis: Interpreting the Genome’ (Speicher D, Ed) Elsevier (in press) |
|
Nice EC, Catime,l, B, Rothacker J, Hall N, BurgessAW, Garrett TPJ, McKern N and Ward CW (2003)Applications of optical biosensors to structurefunction studies on the EGF/EGFR system. In: ‘Methods in Proteome and Protein Analysis (MPSA2002)’ (Kamp RM, Calvete J, Choli-Papadopoulou T and Appella E, Eds) Springer (in press) |
Nice EC, Garrett TPJ, Ward, CW, Lou M-Z, McKern NM, Lovrecz GO, Ellman TC, Adams TE, JorissenRN, Rothacker J, Zhu H, Walker F and Burgess AW(2002) Structure-function studies on the EGF/EGFR family: towards the clinic. In: ‘Proceedings of the Chinese Peptide Symposium, Dalian, 2002’ |
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Wong PKK, Campbell IK, Egan PJ, Ernst M and Wicks IP (2003) The role of the interleukin-6 family of cytokines in inflammatory arthritis and bone turnover. Arth Rheum 48:1177-1189 |
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| 2000/01 |
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| Catimel B, Rothacker J and Nice EC (2001) The use of biosensors for micro-affinity purification: an integrated approach to proteomics. J Biochem Biophys Methods 49:289-312 PubMed Link | Greenhalgh C and Hilton DJ (2000) The regulation of cytokine signalling by the SOCS proteins. The Immunologist 8:45-47 |
| Greenhalgh CJ and Hilton DJ (2001) Negative regulation of cytokines signaling. J Leuk Biol 70:348-356 PubMed Link | Halford MM and Stacker SA (2001) Revelations of the RYK receptor. Bioessays 23:34-45 PubMed Link |
| Kile BT and Alexander WS (2001) The suppressors of cytokine signalling (SOCS) Cell Mol Life Sci 58:1627-35 PubMed Link | Kile BT, Alexander WS and Nicola N (2001) Negative regulation of cytokine signalling. Int J Hematol 73:292-298 PubMed Link |
| Krebs D and Hilton D.J (2000) SOCS: Physiological suppressors of cytokine signaling, J. Cell Sci. 113: 2813-9819 PubMed Link | Krebs DL and Hilton DJ (2001) SOCS proteins: negative regulators of cytokine signaling. Stem Cells 19:378-87 PubMed Link |
| Metcalf D (2001) Hematopoietic stem cells: old and new. Biomedicine and Pharmacotherapy 55:75-78 PubMed Link |
Metcalf D (2001) The nature of hematopoietic cell development
as deducible from clonal cultures. In: ‘Hematopoiesis: A Developmental
Approach’ (Zon L Ed), Oxford University Press |
| Nice EC, Catimel B, Rothacker J, Bathgate R, Mathieu M, Claasz A, Tregear G and Wade JD (2001) The use of biosensor technology to search for orphan biomolecules: towards the relaxin receptor. In: ‘Relaxin 2000. Proceedings of the 3rd International Conference on Relaxin & Related Peptides’, (Tregear GW, Ivell R, Bathgate RA & Wade JD, Eds) Kluwer-ESCOM, Dordrecht (in press) | Nicholson SE and Alexander WS ‘SOCS Proteins in Haemopoiesis’, In: The JAK-STAT pathway in hematopoiesis, Landes Bioscience (Ward AC Ed) (in press). Online publication at: http://www.eurekah.com |
| Nicola NA and Greenhalgh CJ (2000) The suppressors of cytokine signalling (SOCS) proteins: important feedback inhibitors of cytokine action. Exp Haem 28:1105-1112 PubMed Link | Robb L, Dimitriadis E and Salamonsen LA (2001) Leukemia inhibitory factor and inteleukin 11: cytokines with key roles in implantation. J Reproductive Immul (in press) |
| Salamonsen LA, Dimitriadis E and Robb L (2000) Cytokines in Implantation. Sem Reprod Med 18:299-310 PubMed Link |
Starr R (2001) Inhibitors of the JAK/STAT signalling pathway.
In: ‘Cytokine Inhibitors’, Marcel Dekker Inc, New York, pp261-283 |
Media Reports, Press Releases and Articles
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News Release – CRC-CGF - Friday 20th September 2002 ‘Melbourne team makes landmark biomedical discovery’ |
The Weekend Australian, 21st-22nd September 2002, ‘CSIRO in key cancer discovery’. Specifically mentions the CRC for Cellular Growth Factors. |
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ABC Radio National, October 2002, Talk by Prof. Don Metcalf with Margaret Throsby |
The Australian, Higher Education, 13th November 2002, ‘Top-class experience for undergraduates’. A letter from CRC-CGF CEO Dr John Flack and Senior Scientist Dr Doug Hilton about the CRCCGF’s Undergraduate Research Opportunities Program (UROP). |
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News Release - CRC Association - 4th February 2003 ‘Gene Weapons for the War on Disease' |
The Canberra Times, 6th February 2003, ‘Model Molecule’ |
|
Sunday Herald Sun, 9th February 2003, ‘Cancer team’s world first’ |
News Release - CRC-CGF - 28th February 2003 ‘Discovery Opens Possibility of Stopping Cancer Cells Multiplying’ |
|
Courier-Mail, 5th March 2003, ‘Scientists a step closer to effective cancer treatment’ |
Australian Biotechnology News, 7th March 2003, Vol.2 No. 6 ‘Cancer molecule revealed’ |
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The Sydney Morning Herald, 13th March 2003, ‘Health and Science – Negotiating cell secrets a delicate dance for researchers’ |
Newsletter - DEST – Autumn 2003 ‘CRCs: Success Through Innovation’, CRC Snapshots section profiles the CRC-CGF’s work on determining the structure of EGF receptor, a key molecule on the surface of cancer cells. |
|
R&D Review, March 2003, ‘Cancer Protein Nailed’ |
News Release - Amrad Corporation Limited and Medarex – 15th May 2003 ‘Medarex and Amrad Announce Agreement to Develop Therapeutic Antibodies’ |
|
News Release – CRC Association – 22nd June 2003 ‘Commercial Success from Co-operative Research’ |
News Release – Amrad Corporation and Merck Sharp & Dohme – 23rd June 2003 ‘Merck licenses Amrad technology to develop new asthma drugs' |
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ABC News and 7.30 Report, June 2003, Interview of Prof. Don Metcalf |
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| The Herald Sun, 4 December 2001, ‘Net Link to stalk disease’ p26 1st edition. Short article by Maria Moscaritolo on the use of distributed processing to screen for potential therapeutics. The program, written by CRC PhD student Kim Branson, runs as a screen saver during idle time and is distributed by Popular Power. | News Release - CRC-CGF, CSIRO, AMD - 7 December 2000 ‘New supercomputer delivers Australia’s fastest IT weapon to design drugs for fighting disease’ |
| The Age, 11 December 2000, ‘Hunt for Cures now 20,000 times faster’. Article on the design, construction and the launch of the CRC’s supercomputer Caduceus. Launch by State and Regional Development Minister, The Hon. Mr John Brumby. | News Release - AMRAD Corporation Limited - 1 February 2001 ‘AMRAD secures deal with GlaxoSmithKline for exciting new drug discovery program’ |
| The Australian, 20 February 2001, ‘Student’s budget super-PC: a Beowulf cluster for drug design’ | The Science Files Radio Interview, Pegasus Media and CSIRO, February 2001, ‘Computer Aided Drug Design’. |
| Ring B (2000) When 64 athlons are not enough. Atomic Computing Magazine 4:14-16 (an article on the Caduceus Beowulf Cluster) |
Melbourne a biotech magnet, BRW, 23 March 2001, quotes the CRC-CGF Director, Dr Doug Hilton |
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News Release - University of Melbourne Lectureship Program - 9 May 2001 in relation to the Science Meets Art event ‘Genetically Modified Ps’ |
Education
Times, 7 June 2001, ‘DNA helps students learn about peas’
|