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Tumour Targeting Laboratory
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Our laboratory research has focused on the development and preclinical characterization of targeting strategies to tumours with recombinant antibodies and signalling inhibitors for diagnostic and therapeutic applications. Current studies are investigating the enhancement of antibody immune function, the mechanisms of antibody-antigen binding and intracellular movement through cancer cells, and the generation of custom designed constructs through genetic engineering.

Our laboratories also support clinical trials through the preparation of radiolabelled reagents for administration to patients and the analysis of patient sera samples for pharmacokinetic and immunological response data. Collaborations with the Austin Hospital's Departments of Nuclear Medicine and Anatomical Pathology facilitate biodistribution analyses and immunohistochemical studies, respectively.

As part of the LICR's global Antibody Targeting Program, Phase I trials in colon, breast, lung, melanoma, glioma and renal cell cancers examining the safety, biodistribution and pharmacokinetics of recombinant antibodies have been conducted.

 

Recent Publications

1. Ma, Y., C. Kowolik, P.M. Swiderski, M. Kortylewski, H. Yu, D.A. Horne, R. Jove, O.L. Caballero, A.J. Simpson, F.T. Lee, V. Pillay, and A.M. Scott, Humanized Lewis-Y specific antibody based delivery of STAT3 siRNA. ACS Chem Biol, 2011.

2. Garrett, T.P., Burgess, A.W., Gan, H.K., Luwor, R.B., Cartwright, G., Walker, F., Orchard, S.G., Clayton, A.H., Nice, E.C., Rothacker, J., Catimel, B., Cavenee, W.K., Old, L.J., Stockert, E., Ritter, G., Adams, T.E., Hoyne, P.A., Wittrup, D., Chao, G., Cochran, J.R., Luo, C., Lou, M., Huyton, T., Xu, Y., Fairlie, W.D., Yao, S., Scott, A.M., and Johns, T.G., Antibodies specifically targeting a locally misfolded region of tumor associated EGFR. Proc Natl Acad Sci U S A, 2009. 106(13): p. 5082-7.

3. Herbertson, R.A., Tebbutt, N.C., Lee, F.T., Macfarlane, D.J., Chappell, B., Micallef, N., Lee, S.T., Saunder, T., Hopkins, W., Smyth, F.E., Wyld, D.K., Bellen, J., Sonnichsen, D.S., Brechbiel, M.W., Murone, C., and Scott, A.M., Phase I Biodistribution and Pharmacokinetic Study of Lewis Y-Targeting Immunoconjugate CMD-193 in Patients with Advanced Epithelial Cancers. Clin Cancer Res, 2009. 15(21): p. 6709-15.

4. Kelly, M.P., Lee, S.T., Lee, F.T., Smyth, F.E., Davis, I.D., Brechbiel, M.W., and Scott, A.M., Therapeutic efficacy of 177Lu-CHX-A''-DTPA-hu3S193 radioimmunotherapy in prostate cancer is enhanced by EGFR inhibition or docetaxel chemotherapy. Prostate, 2009. 69(1): p. 92-104.

5. Scott, A.M., Gunawardana, D.H., Kelley, B., Stuckey, J.G., Byrne, A.J., Ramshaw, J.E., and Fulham, M.J., PET changes management and improves prognostic stratification in patients with recurrent colorectal cancer: results of a multicenter prospective study. J Nucl Med, 2008. 49(9): p. 1451-7.

6. Scott, A.M., Lee, F.T., Tebbutt, N., Herbertson, R., Gill, S.S., Liu, Z., Skrinos, E., Murone, C., Saunder, T.H., Chappell, B., Papenfuss, A.T., Poon, A.M., Hopkins, W., Smyth, F.E., MacGregor, D., Cher, L.M., Jungbluth, A.A., Brechbiel, M.W., Murphy, R., Burgess, A.W., Hoffman, E.W., Johns, T.G., and Old, L.J., A phase I clinical trial with monoclonal antibody ch806 targeting transitional state and mutant epidermal growth factor receptors. Proc Natl Acad Sci U S A, 2007. 104(10): p. 4071-6.

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Research Links
icon Overview
icon Tumour Targeting Laboratory
icon Cancer Immunobiology Laboratory
icon T Cell Laboratory
icon Uro-Oncology Laboratory
icon Oncogenic Transcription Laboratory
icon Joint Austin Ludwig Oncology Unit
icon Centre for PET
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Tumour Targeting Lab Staff
Laboratory Head
Professor Andrew Scott
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Staff Directory

Andrew Scott - Director, Laboratory Head
FT Lee - Senior Investigator
Zhanqi Liu - Associate Investigator
Ingrid Burvenich - Postdoctoral Fellow
Nathalie Dhomen - Postdoctoral Fellow
Vino Pillay - Postdoctoral Fellow
Sze Ting Lee - Senior Clinical Research Fellow
Nathan Lawrentschuk - Senior Clinical Research Fellow
Marika Ciprotti - Clinical Research Fellow
Angela Vitali - Senior Research Officer
Laura Allan - Senior Research Officer
Violeta Spirkoska - Senior Research Officer
Rachel Canfield - Research Officer
Dahna Makris - Research Assistant
Malarmathy Ramachandran - Research Assistant
Nancy Guo - Research Assistant
Pece Kocovski - Research Assistant
Rose Bogdal - Research Assistant
Simone Reisman - Data Manager
Dylan King - Ph.D. Student

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Of Note

Grants

Andrew Scott
ACRF Capital Works & Facilities Grant 2012-2013
Cancer Council Victoria Project Grant 2012-2014
NH&MRC Development Grant 2012-2014
NH&MRC Program Grant 2009-2012
NH&MRC Project Grant 2012-2014

FT Lee
NH&MRC Project Grant 2011-2013

Hui Gan
AHMRF Bernie Sweet Fellowship 2012
Victorian Cancer Agency Fellowship 2011-2012

 
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