UroOncology Laboratory - LICR Melbourne-Austin Branch

LICR MELBOURNE-AUSTIN BRANCH

Research > UroOncology Lab

Uro-Oncology Lab

The Uro-Oncology Laboratory is studying cancers related to the urinary system: kidney, prostate and bladder cancers. These cancers are highly prevalent in Australia, but current treatments are not ideal. As we understand the basic biology of these cancers more clearly, we are discovering new potential targets for treatment.

The LICR Uro-Oncology Laboratory, which has very close interactions with the surgeons and cancer specialists who care for these patients, will examine the processes underlying the causes and growth of these cancers.

Research in our laboratory will specifically concentrate on the nature of stem cells in these cancers, how these cancers use signalling pathways within the cell, how they interact with their environment, how they are recognised by and interact with the immune system, and how these processes correlate with the clinical outcomes and responses to treatment we observe in these patients.

These research projects will involve collaboration with the other research groups within the LICR Melbourne-Austin Branch, other programs within LICR, and other Australian and international collaborators.

Publications

1. J. Chang, D. Lim Joon, S. Lee, S. Gong, A.M. Scott, I.D. Davis, D. Cloutston, D. Bolton, A. Hamiltron, and V. Khoo. "Histopathological correlation of 11C-choline PET scans for target volume definition in radical prostate radiotherapy". Radiotherapy and Oncology. (99): p. 187-92. 2011.

2. N. Rajarubendra, N. Lawrentschuk, D.M. Bolton, L. Klotz, and I.D. Davis. "Prostate cancer immunology - an update for Urologists". BJU Int. 107(7): p. 1046-51 2011.

3. T.E. Hutson, I.D. Davis, J.P. Machiels, P.L. De Souza, S. Rottey, B.F. Hong, R.J. Epstein, K.L. Baker, L. McCann, T. Crofts, L. Pandite, and R.A. Figlin. "Efficacy and safety of pazopanib in patients with metastatic renal cell carcinoma". J Clin Oncol. 28(3): p. 475-80 2010

4. N. Lawrentschuk, I.D. Davis, D.M. Bolton, and A.M. Scott. "Functional imaging of renal cell carcinoma". Nat Rev Urol. 7(5): p. 258-66 2010.

5. G.P. Risbridger, I.D. Davis, S.N. Birrell, and W.D. Tilley. "Breast and prostate cancer: more similar than different". Nat Rev Cancer. 10(3): p. 205-12 2010.

6. C.N. Sternberg, I.D. Davis, J. Mardiak, C. Szczylik, E. Lee, J. Wagstaff, C.H. Barrios, P. Salman, O.A. Gladkov, A. Kavina, J.J. Zarba, M. Chen, L. McCann, L. Pandite, D.F. Roychowdhury, and R.E. Hawkins. "Pazopanib in locally advanced or metastatic renal cell carcinoma: results of a randomized phase III trial". J Clin Oncol. 28(6): p. 1061-8 2010.

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Research Links

	Overview
	Tumour Targeting Laboratory
	Cancer Immunobiology Laboratory
	T Cell Laboratory
	Uro-Oncology Laboratory
	Oncogenic Transcription Laboratory
	Joint Austin Ludwig Oncology Unit
	Centre for PET
	Key Technologies

Uro-Oncology Lab Staff

Laboratory Head

A/Prof. Ian Davis

Staff Directory

Ian Davis - Laboratory Head
Pavel Sluka - Postdoctoral Fellow
Manvendra Saxena - Postdoctoral Fellow
Lekshmy Shanker - Project Co-ordinator
Genevieve Whitty - Research Assistant
Rebecca Nightingale - Research Assistant
Dixon Woon - Honorary Scientist
James Lynam - MD Student

Of Note

Grants

Ian Davis
Cancer Australia Priority Driven Cancer Research Scheme 2008-2012
Cancer Australia/ Prostate Cancer Foundation of Australia Project Grant 2010-2012
Prostate Cancer Foundation of Australia NDDA Grant 2012-2013
NH&MRC Practitioner Fellowship 2008-2012