The Angiogenesis Laboratory is focused on the study of growth factors and their receptors which are involved in tumor growth and metastasis. In particular we are exploring the role of blood and lymphatic vessels in the progression of cancer.

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The Signal Transduction Laboratory is focused on the study of inhibitory signaling pathways in haematopoietic cells that have been linked to cancer, inflammatory and autoimmune diseases. We are particularly interested in pathways involving the Src-family protein tyrosine kinase Lyn.

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Our laboratory is studying the signaling systems which influence the production and function of colonic cells. At present we are focusing on the EGF receptor, wnt and integrin signaling systems. We are identifying and analyzing the mutations and proteins which characterize normal and cancerous stem cells in both mice and humans. We aim to use the differences between the signaling systems of normal and cancerous colon cells to develop targeted treatments for improving outcomes for colon cancer patients.

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Studies conducted in the Colon Molecular and Cell Biology Laboratory are designed to identify and characterize the properties of genes and pathways involved in the development and progression of cancer of the colon and stomach.

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The Joint ProteomicS Laboratory, a joint initiative of the Ludwig Institute for Cancer Research and the Walter and Eliza Hall Institute of Medical Research, continues to focus on analytical biochemistry, technical developments in protein separation and characterisation, and Proteomics.

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The goal of the cell biophysics laboratory is to
(a) develop novel biophysical tools for the measurement of protein conformation and protein-protein interaction in living cells and
(b) apply these tools to gain a quantitative understanding of the initiation and progression of signaling pathways and how they become disregulated in cancer.

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There are a number of platform technologies which are utilised at the Branch.

The JPSF has established a world-class protein identification and analysis capability for use by the scientists of WEHI and LICR. The scientists of the JPSF are available to advise scientists on the processes available to enrich particular proteins in biological extracts.

JPSF applies powerful electrophoretic, chromatographic, mass spectrometric and bioinformatic analysis techniques to identify the proteins present in complex mixtures. The results generated are reported to scientists in a timely fashion.

The JPSF is located on the 8th Floor of the East-wing of the Royal Melbourne Hospital complex. Potential users of the JPSF are welcome to visit the facilities: simply contact the JPSF Manager, Dr. Robert Moritz.

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The Central Resource for Advanced Microscopy is a service core facility to provide microscopy in support of the Institute's research and clinical programs.

The facility is equipped with two confocal microscopes, a fluorescence lifetime imaging system, a motorized wide field fluorescent inverted microscope, a motorized upright microscope and a fluorescence capable stereo microscope. Most systems are capable of live cell imaging.

We aim to assist planning experiments, training individuals the microscopy techniques they require in their research, and on occasion collaborating in their research.

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The group has had a long term interest in the development of special techniques for the purification of very low levels of biochemicals (e.g. proteins, peptides, prostoglandins, lipids) present in biological samples at trace levels. We use these purified compounds to understand both their structure (shape) and function (biological activity).

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