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Tumour Targeting Laboratory
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Our laboratory research has focused on the development and preclinical characterization of targeting strategies to tumours with recombinant antibodies and signalling inhibitors for diagnostic and therapeutic applications. Current studies are investigating the enhancement of antibody immune function, the mechanisms of antibody-antigen binding and intracellular movement through cancer cells, and the generation of custom designed constructs through genetic engineering.

Our laboratories also support clinical trials through the preparation of radiolabelled reagents for administration to patients and the analysis of patient sera samples for pharmacokinetic and immunological response data. Collaborations with the Austin Hospital's Departments of Nuclear Medicine and Anatomical Pathology facilitate biodistribution analyses and immunohistochemical studies, respectively.

As part of the LICR's global Antibody Targeting Program, Phase I trials in colon, breast, lung, melanoma, glioma and renal cell cancers examining the safety, biodistribution and pharmacokinetics of recombinant antibodies have been conducted.

 

Recent Publications

1. Garrett, T.P., Burgess, A.W., Gan, H.K., Luwor, R.B., Cartwright, G., Walker, F., Orchard, S.G., Clayton, A.H., Nice, E.C., Rothacker, J., Catimel, B., Cavenee, W.K., Old, L.J., Stockert, E., Ritter, G., Adams, T.E., Hoyne, P.A., Wittrup, D., Chao, G., Cochran, J.R., Luo, C., Lou, M., Huyton, T., Xu, Y., Fairlie, W.D., Yao, S., Scott, A.M., and Johns, T.G., Antibodies specifically targeting a locally misfolded region of tumor associated EGFR. Proc Natl Acad Sci U S A, 106(13): p. 5082-7 2009.

2. Kelly, M.P., Lee, S.T., Lee, F.T., Smyth, F.E., Davis, I.D., Brechbiel, M.W., and Scott, A.M., Therapeutic efficacy of 177Lu-CHX-A''-DTPA-hu3S193 radioimmunotherapy in prostate cancer is enhanced by EGFR inhibition or docetaxel chemotherapy. Prostate, 69(1): p. 92-104 2009.

3. Pillay, V., Allaf, L., Wilding, A.L., Donoghue, J.F., Court, N.W., Greenall, S.A., Scott, A.M., and Johns, T.G., The plasticity of oncogene addiction: implications for targeted therapies directed to receptor tyrosine kinases. Neoplasia, 11(5): p. 448-58, 2 p following 458 2009.

4. Scott, A.M., Gunawardana, D.H., Kelley, B., Stuckey, J.G., Byrne, A.J., Ramshaw, J.E., and Fulham, M.J., PET changes management and improves prognostic stratification in patients with recurrent colorectal cancer: results of a multicenter prospective study. J Nucl Med, 49(9): p. 1451-7 2008.

5. Li, D., Ji, H., Zaghlul, S., Mcnamara, K., Liang, M.C., Shimamura, T., Kubo, S., Takahashi, M., Chirieac, L.R., Padera, R.F., Scott, A.M., Jungbluth, A.A., Cavenee, W.K., Old, L.J., Demetri, G.D., and Wong, K.K., Therapeutic anti-EGFR antibody 806 generates responses in murine de novo EGFR mutant-dependent lung carcinomas. J Clin Invest, 117(2): p. 346-52 2007.

6. Scott, A.M., Lee, F.T., Tebbutt, N., Herbertson, R., Gill, S.S., Liu, Z., Skrinos, E., Murone, C., Saunder, T.H., Chappell, B., Papenfuss, A.T., Poon, A.M., Hopkins, W., Smyth, F.E., Macgregor, D., Cher, L.M., Jungbluth, A.A., Brechbiel, M.W., Murphy, R., Burgess, A.W., Hoffman, E.W., Johns, T.G., and Old, L.J., A phase I clinical trial with monoclonal antibody ch806 targeting transitional state and mutant epidermal growth factor receptors. Proc Natl Acad Sci U S A, 104(10): p. 4071-6 2007.

7. Scott, A.M., Tebbutt, N., Lee, F.T., Cavicchiolo, T., Liu, Z., Gill, S., Poon, A.M., Hopkins, W., Smyth, F.E., Murone, C., Macgregor, D., Papenfuss, A.T., Chappell, B., Saunder, T.H., Brechbiel, M.W., Davis, I.D., Murphy, R., Chong, G., Hoffman, E.W., and Old, L.J., A Phase I Biodistribution and Pharmacokinetic Trial of Humanized Monoclonal Antibody Hu3s193 in Patients with Advanced Epithelial Cancers that Express the Lewis-Y Antigen. Clin Cancer Res, 13(11): p. 3286-92 2007.

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Tumour Targeting Lab Staff
Laboratory Head
Professor Andrew Scott
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Staff Directory

Andrew Scott - Director, Laboratory Head
FT Lee - Senior Investigator
Zhanqi Liu - Associate Investigator
Ingrid Burvenich - Postdoctoral Fellow
Sarah Baird - Postdoctoral Fellow
Vino Pillay - Postdoctoral Fellow
David Pook - Clinical Research Fellow
Angela Vitali - Senior Research Officer
Laura Allan - Senior Research Officer
Violeta Spirkoska - Senior Research Officer
Xin Song - Senior Research Officer
Rachel Canfield - Research Officer
Marzena Walkiewicz - Research Assistant
Dahna Makris - Research Assistant
Malarmathy Ramachandran - Research Assistant
Sze Ting Lee - Ph.D. Student

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Of Note

Grants

Andrew Scott
NH&MRC Project Grant 2009-2011
Atlantic Philanthropies Foundation 2006-2009
Cancer Australia Project Grant 2008-2011
NH&MRC Program Grant 2009-2012

 
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