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Dr FT Lee
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Laboratory
Tumour Targeting Laboratory

Degrees
B.Sc (Hons), Univ. of London
Ph.D., Univ. of Newcastle Upon Tyne, UK

Post-Doc

Areas of Interest
  1. Targeting of tumours using antibodies in pre-clinical and clinical trials
  2. Develop novel radio-immunoconjugates
  3. Intra-cellular trafficking of antibody/antigen complex
  4. Radioimmunotherapy of cancers and in combination with chemotherapy.
Current Students
Hot Topic
  • Targeting breast cancer using humanised anti-Lewisy monoclonal antibody (hu3S193) in mouse model and in patients
  • Synergistic effects of antibody and cell cycle specific chemotherapy
  • Develop radioimmunoconjugates with isotopes such as Yttrium-90 (beta emitters) or Gallium- 67 (auger electron) for cellular or intra-cellular tumour targeting
  • Cellular trafficking of antibody/antigen complex
  • Mechanism(s) of tumour response to antibody therapy in CD19+ and CD30+ neoplasms
Publication Snapshot
  1. Clarke, K., Lee, FT, Brechbiel, M., Smyth, F., Richards, E., Stockert, E., Old, LJ., and Scott, AM. (2000) Clinical Cancer Res. 6: 3621-3628. "Therapeutic efficacy of anti-Lewisy humanised 3S193 radioimmunotherapy in a breast cancer model: enhanced activity when combined with taxol chemotherapy".
  2. Lee, FT, Hall, C., Rigopoulos, A., Brechbiel, M., Gansow, O., Welt, S., Old, LJ. Burgess, A., and Scott, AM (2001) Cancer Res 61: 4474-4482 "Specific Localisation, Gamma Camera Imaging and Intracellular Trafficking of Radiolabelled Anti-GD3 Monoclonal Antibody in a Melanoma Xenograft"
  3. Lee, FT, Hall, C., Rigopoulous, A., Pathmaraj, K., Hannah, A., Zweit, J., Welt, S., Old, LJ and Scott, AM (2001) J. Nucl. Med. 42:764-769. "Immuno-positron emission tomography of human colon xenograft bearing BALB/c nude mice using 124I-CDR-grafted humanised A33 antibody".
  4. Tahtis, K., Lee, F.T., Smyth, F.E., Power, B.E., Renner, C., Brechbiel, MW, Old, LJ, Hudson, PJ and Scott, AM (2001) Clin. Cancer Res. 7:1061-1072. "Biodistribution properties of 111In-CHX-A"-DTPA humanised 3S193 diabody and F(ab')2 constructs in a breast carcinoma xenograft model".
  5. Renner, C., Stehle, I., Lee, FT, Hall, C., Catimel, B. Nice, E., Mountain, A., Rigopoulos, A., Pfreundschuh, M., Scott, A. (2001) Cancer Immunol Imunother.50:102-108. Targeting properties of an anti-CD16/anti-CD-CD30 bispecific antibody in an in-vivo system".
  6. Andrew M. Scott, Fook-Thean Lee, Wendie Hopkins, Jonathan S. Cebon, Jennifer M. Wheatley ,Zhanqi Liu, Fiona E. Smyth, Carmel Murone, Susan Sturrock, Duncan MacGregor, Nobuo Hana, Kengo Inoue, Martin W. Brechbiel, Ian D. Davis, Roger Murphy, Anthony Hannah, Michael Lim-Joon, Tony Chan, Geoffrey Chong, Gerd Ritter, Eric W. Hoffman, Antony W. Burgess, Lloyd J. Old (2001) In press. J.Clin. Oncol. "Specific targeting, biodistribution and lack of immunogenicity of chimeric anti-GD3 monoclonal antibody KM871 in patients with metastatic melanoma - results of a phase I trial.
  7. Lee, FT, Hall, C., Rigopoulous, A., Brechbiel, M., Gansow, O., Welt, S., Old, LJ and Scott, AM (manuscript in preparation) "Analysis of tumour targeting, intratumoural distribution and cellular trafficking of radiolabelled monoclonal antibody huA33 in a SW1222 xenografted BALB/c nude mouse colon cancer model."

 

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Other Information
icon Supervisors
  icon Professor Andrew Scott
  icon Professor Jonathan S. Cebon
  icon Assoc. Professor Weisan Chen
  icon Assoc. Professor Ian Davis
  icon Assoc. Professor John Mariadason
  icon Dr FT Lee
  icon Dr Niall Tebbutt
icon Current Students
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