PPT Slide

Scoring (Substitution) Matrices

• Physico-chemical
  • Charge and structural properties (Karlin and Ghandour, 1985)
  • Structural and genetic properties (Feng, Johnson, and Doolittle, 1985)
  • Hydrophobicity pattern

• Mutational
  • PAM (M. O. Dayhoff, 1978)
  • BLOSUM (Henikoff and Henikoff, 1992)
  • GONNET (Gonnet, Cohen, and Benner, 1992)

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