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Epithelial Biochemistry Laboratory Andrew Clayton BSc(Hons), PhD Human Frontier Science Program Research Fellow

Current work: structure-function studies on the EGF/EGF receptor family; development of fluorescence microscopy techniques

Research Interests: fluorescence studies of proteins; FRET techniques; multidimensional microscopy

Publication Snapshot:
Photophysics of green and red fluorescent proteins: some implications for quantitative microscopy
Subramaniam V, Hanley QS, Clayton AHA, Jovin TM.
Methods Enzymol. In Press

Dynamic Fluorescence Anisotropy Imaging Microscopy in the Frequency Domain (rFLIM).
Clayton AH, Hanley QS, Arndt-Jovin DJ, Subramaniam V, Jovin TM.
Biophys J. 83: 1631-1649 (2002). [Medline entry]

Site-specific tryptophan fluorescence spectroscopy as a probe of membrane peptide structure and dynamics.
Clayton AH, Sawyer WH.
Eur Biophys J. 31: 9-13 (2002). [Medline entry]

Kinetics of membrane lysis by custom lytic peptides and peptide orientations in membrane.
Chen HM, Clayton AH, Wang W, Sawyer WH.
Eur J Biochem. 268: 1659-1669 (2001). [Medline entry]

Oriented circular dichroism of a class A amphipathic helix in aligned phospholipid multilayers.
Clayton AH, Sawyer WH.
Biochim Biophys Acta. 1467: 124-130 (2000). [Medline entry]

Site-specific tryptophan dynamics in class A amphipathic helical peptides at a phospholipid bilayer interface.
Clayton AH, Sawyer WH.
Biophys J. 79: 1066-1073 (2000). [Medline entry]

Helix-helix association of a lipid-bound amphipathic alpha-helix derived from apolipoprotein C-II.
MacPhee CE, Howlett GJ, Sawyer WH, Clayton AH.
Biochemistry. 38: 10878-10884 (1999). [Medline entry]

Tryptophan rotamer distributions in amphipathic peptides at a lipid surface.
Clayton AH, Sawyer WH.
Biophys J. 76: 3235-3242 (1999). [Medline entry]

The structure and orientation of class-A amphipathic peptides on a phospholipid bilayer surface.
Clayton AH, Sawyer WH.
Eur Biophys J. 28: 133-141 (1999). [Medline entry]

Spectral properties of fluorescein in solvent-water mixtures: applications as a probe of hydrogen bonding environments in biological systems.
Klonis N, Clayton AH, Voss EW Jr, Sawyer WH.
Photochem Photobiol. 67: 500-510 (1998). [Medline entry]