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Epithelial Biochemistry Laboratory Bruno Catimel MBS DEA PhD Research Fellow, Assistant Investigator

Current work: Development of novel strategies for protein micropurification/proteomics and biosensor analysis; Analysis of the APC tumour suppressor gene product; Role of laminin-10 in colon cancer metastasis; Purification and characterisation of a putative neutrophil activation factor

Research Interests: protein purification; analysis of protein-protein interactions using biosensor technology; micropreparative HPLC; proteomics

Publication Snapshot:
The use of coiled-coil interactions for the analysis and micropreparative isolation of adenomatous polyposis coli protein complexes.
Catimel B, Faux MC, Nerrie M, Rothacker J, Otvos LJ, Wade JD, Nice EC, Burgess AW.
J Pept Res. 58: 493-503 (2001). [Medline entry]

Biosensors and Proteomics.
Catimel B, Rothacker J, Nice EC.
Todays Life Science. 14(1): 24-30 (2002).

The use of biosensors for microaffinity purification: an integrated approach to proteomics.
Catimel B, Rothacker J, Nice E.
J Biochem Biophys Methods. 49: 289-312 (2001). [Medline entry]

Structural and biosensor analyses of a synthetic biotinylated peptide probe for the isolation of adenomatous polyposis coli tumor suppressor protein complexes.
Wade JD, Catimel B, Faux MC, Burgess AW, Nice E, Otvos L.
J Pept Res. 58:204-212 (2001). [Medline entry]

Isolated lymphatic endothelial cells transduce growth, survival and migratory signals via the VEGF-C/D receptor VEGFR-3. Mäkinen T, Veikkola T, Mustjoki S, Karpanen T, Catimel B, Nice EC, Wise L, Mercer A, Kowalski H, Kerjaschki D, Stacker SA, Achen MG, Alitalo K. EMBO J. 2001 Sep 3;20(17):4762-73. [Medline entry]

Biophysical characterization of interactions involving importin-alpha during nuclear import.
Catimel B, Teh T, Fontes MR, Jennings IG, Jans DA, Howlett GJ, Nice EC, Kobe B.
J Biol Chem. 276: 34189-34198 (2001). [Medline entry]

Targeting properties of an anti-CD16/anti-CD30 bispecific antibody in an in vivo system.
Renner C, Stehle I, Lee FT, Hall C, Catimel B, Nice EC, Mountain A, Rigopoulos A, Brechbiel MW, Pfreundschuh M, Scott AM.
Cancer Immunol Immunother. 50: 102-108 (2001). [Medline entry]

Synthesis, conformational studies and biological activity of N(alpha)-mono-biotinylated rat relaxin.
Mathieu MN, Wade JD, Catimel B, Bond CP, Nice EC, Summers RJ, Otvos L Jr, Tregear GW.
J Pept Res. 57: 374-382 (2001). [Medline entry]

Design of inhibitors of Ras-Raf interaction using a computational combinatorial algorithm.
Zeng J, Nheu T, Zorzet A, Catimel B, Nice E, Maruta H, Burgess AW, Treutlein HR.
Protein Eng. 14: 39-45 (2001). [Medline entry]

The specificity of receptor binding by vascular endothelial growth factor-D is different in mouse and man.
Baldwin ME, Catimel B, Nice EC, Roufail S, Hall NE, Stenvers KL, Karkkainen MJ, Alitalo K, Stacker SA, Achen MG.
J Biol Chem. 276: 19166-19171 (2001). [Medline entry]

c-Raf-1 RBD associates with a subset of active v-H-Ras.
Fridman M, Walker F, Catimel B, Domagala T, Nice E, Burgess A.
Biochemistry. 39: 15603-15611 (2000). [Medline entry]

Miniturization of HPLC separations and equipment in peptide and protien analysis.
Nice EC, Catimel B.
In Encyclopedia of Analytical Chemistry (EAC: Instrumentation and applications). RA Meyers, Editor. John Wiley and Sones Ltd, Chcichester, UK, 7: 5823-5845 (2000).

Mutagenesis and selection of PDZ domains that bind new protein targets.
Schneider S, Buchert M, Georgiev O, Catimel B, Halford M, Stacker SA, Baechi T, Moelling K, Hovens CM.
Nat Biotechnol. 17: 170-175 (1999). [Medline entry]

Instrumental biosensors: new perspectives for the analysis of biomolecular interactions.
Nice EC, Catimel B.
Bioessays. 21: 339-352 (1999). [Medline entry]