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Epithelial Biochemistry Laboratory Francesca Walker PhD Research Fellow, Associate Investigator

Current work: EGF receptor signalling: role in transformation and cell cycle progression; Structure-Function studies on the EGF/EGF receptor family; Preclinical studies of EGF receptor inhibitor AG1478; Purification and characterisation of a putative neutrophil activation factor

Research Interests: signalling pathways in general; cell cycle control

Publication Snapshot:
Epidermal Growth Factor Receptor: Self-association of Extracellular Domain Negatively Regulates Intracellular Kinase Activation in the Absence of Ligand.
H-J Zhu J Iaria, S Orchard, F Walker, AW Burgess.
Submitted

Crystal structure of a truncated epidermal growth factor receptor extracellular domain bound to transforming growth factor alpha
Garrett TPJ, McKern NM, Lou M, Elleman TC, Adams TE, Lovrecz GO, Zhu H-J, Walker F, Frenkel MJ, Hoyne PA, Jorissen RN, Nice EC, Burgess AW, Ward CW.
Cell. 110: 763-773 (2002). [Medline entry]

Rapid microscale enzymic semisynthesis of epidermal growth factor (EGF) analogues.
Nice EC, Domagala T, Fabri L, Nerriea M, Walker F, Jorissen RN, Burgess AW, Cui DF, Zhang YS.
Growth Factors. 20: 71-80 (2002). [Medline entry]

He H, Levitzki A, Zhu HJ, Walker F, Burgess A, Maruta H.
Platelet-derived growth factor requires epidermal growth factor receptor to activate p21-activated kinase family kinases.
J Biol Chem. 276: 26741-26744 (2001). [Medline entry]

Expression of EGFR-family proteins in the brain: role in development, health and disease.
Novak U, Walker F, Kaye A.
J Clin Neurosci. 8: 106-111 (2001). [Medline entry]

RING finger mutations that abolish c-Cbl-directed polyubiquitination and downregulation of the EGF receptor are insufficient for cell transformation.
Thien CB, Walker F, Langdon WY.
Mol Cell. 7: 355-365 (2001). [Medline entry]

c-Raf-1 RBD associates with a subset of active v-H-Ras.
Fridman M, Walker F, Catimel B, Domagala T, Nice E, Burgess A.
Biochemistry. 39: 15603-15611 (2000). [Medline entry]

Point mutants of c-raf-1 RBD with elevated binding to v-Ha-Ras.
Fridman M, Maruta H, Gonez J, Walker F, Treutlein H, Zeng J, Burgess A.
J Biol Chem. 275:30363-30371 2000. [Medline entry]

Activation of the Ras/mitogen-activated protein kinase pathway by kinase-defective epidermal growth factor receptors results in cell survival but not proliferation.
Walker F, Kato A, Gonez LJ, Hibbs ML, Pouliot N, Levitzki A, Burgess AW.
Mol Cell Biol. 18: 7192-7204 (1998). [Medline entry]

Biochemical characterization of mutant EGF receptors expressed in the hemopoietic cell line BaF/3.
Walker F, Hibbs ML, Zhang HH, Gonez LJ, Burgess AW.
Growth Factors. 16: 53-67 (1998). [Medline entry]