![[LICR logo]](logo.gif){kind=logo}
Epithelial Biochemistry LaboratoryHong-Jian ZhuBSc, PhD
|
|
Current work: TGF-beta receptor signalling; Tumour suppressor PTEN and oncogene Ras; Mechanisms of EGF receptor activation
Research Interests: signal transduction
Publication Snapshot:
Heart and Liver Defects and Reduced Transforming Growth Factor-beta2 Sensitivity in
Transforming Growth Factor-beta Type III Receptor-Deficient Embryos.
Stenvers KL, Tursky ML, Kountouri N, Amatayakul-Chantler S, Grail D, Small C,
Weinberg RA, Sizeland AM, Zhu H-J.
Submitted
Crystal structure of a truncated epidermal growth factor receptor extracellular domain bound
to transforming growth factor alpha
Garrett TPJ, McKern NM, Lou M, Elleman TC, Adams TE, Lovrecz GO, Zhu H-J, Walker F, Frenkel MJ,
Hoyne PA, Jorissen RN, Nice EC, Burgess AW, Ward CW.
Cell. 110: 763-773 (2002).
[Medline entry]
Smad7 inhibits fibrotic effect of tgf-Beta on renal tubular epithelial cells by blocking
smad2 activation.
Li JH, Zhu HJ, Huang XR, Lai KN, Johnson RJ, Lan HY.
J Am Soc Nephrol. 13: 1464-1472 (2002).
[Medline entry]
Regulation of Transforming Growth Factor-beta Signaling.
Zhu HJ, Burgess AW.
Mol Cell Biol Res Commun. 4: 321-330 (2001).
[Medline entry]
Platelet-derived growth factor requires epidermal growth factor receptor to activate p21-activated
kinase family kinases.
He H, Levitzki A, Zhu HJ, Walker F, Burgess A, Maruta H.
J Biol Chem. 276: 26741-26744 (2001).
[Medline entry]
Smad7 differentially regulates transforming growth factor beta-mediated signaling pathways.
Zhu HJ, Iaria J, Sizeland AM.
J Biol Chem. 274: 32258-32264 (1999).
[Medline entry]
Extracellular domain of the transforming growth factor-beta receptor negatively regulates
ligand-independent receptor activation.
Zhu HJ, Sizeland AM.
J Biol Chem. 274: 29220-29227 (1999).
[Medline entry]
A pivotal role for the transmembrane domain in transforming growth factor-beta receptor activation.
Zhu HJ, Sizeland AM.
J Biol Chem. 274: 11773-11781 (1999).
[Medline entry]