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Epithelial Biochemistry Laboratory Josie Iaria BAppSc Senior Research Officer

Current work: TGF-beta receptor signalling; Tumour suppressor PTEN and oncogene Ras; Mechanisms of EGF receptor activation

Research Interests: cell signalling

Publication Snapshot:
Epidermal Growth Factor Receptor: Self-association of Extracellular Domain Negatively Regulates Intracellular Kinase Activation in the Absence of Ligand.
H-J Zhu J Iaria, S Orchard, F Walker, AW Burgess.
Submitted

Smad7 differentially regulates transforming growth factor beta-mediated signaling pathways.
Zhu HJ, Iaria J, Sizeland AM.
J Biol Chem. 274:32258-32264 (1999). [Medline entry]

Identification of a ligand-binding site on the granulocyte colony-stimulating factor receptor by molecular modeling and mutagenesis.
Layton JE, Iaria J, Smith DK, Treutlein HR.
J Biol Chem. 272:29735-29741 (1997). [Medline entry]

Neutralising antibodies to the granulocyte colony-stimulating factor receptor recognise both the immunoglobulin-like domain and the cytokine receptor homologous domain.
Layton JE, Iaria J, Nicholson SE.
Growth Factors. 1997;14(2-3):117-30. [Medline entry]