Epithelial lab front page

Lab head

Current Research

Laboratory staff

Selected Publications

New Stuff

Epithelial Biochemistry Laboratory Kellie Cartledge BSc(Hons) Senior Research Officer

Current work: TGF-beta receptor signalling; Tumour suppressor PTEN and oncogene Ras; Mechanisms of EGF receptor activation

Research Interests: cell signalling

Publication Snapshot:
The molecular chaperone Hsp90 is required for signal transduction by wild-type Hck and maintenance of its constitutively active counterpart.
Scholz GM, Hartson SD, Cartledge K, Volk L, Matts RL, Dunn AR.
Cell Growth Differ. 12: 409-417 (2001). [Medline entry]

Identification and characterization of Harc, a novel Hsp90-associating relative of Cdc37.
Scholz GM, Cartledge K, Hall NE.
J Biol Chem. 276: 30971-30979 (2001). [Medline entry]

Cartledge K, Dunn AR, Scholz G.
Generation and characterization of monoclonal antibodies to the Src-family kinase Hck.
Hybridoma. 19: 323-330 (2000). [Medline entry]

p50(Cdc37) can buffer the temperature-sensitive properties of a mutant of Hck.
Scholz G, Hartson SD, Cartledge K, Hall N, Shao J, Dunn AR, Matts RL.
Mol Cell Biol. 20: 6984-6995 (2000). [Medline entry]

Hck enhances the adherence of lipopolysaccharide-stimulated macrophages via Cbl and phosphatidylinositol 3-kinase.
Scholz G, Cartledge K, Dunn AR.
J Biol Chem. 275: 14615-14623 (2000). [Medline entry]