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Epithelial Biochemistry Laboratory Martin Lackmann BSc(Hons), PhD Senior Research Fellow

Current work: EphA3 signal transduction pathways and function in normal and oncogenic development; Structure/function analysis of Eph-receptor ephrin-ligand interactions and development of inhibitors

Research Interests: ...

Publication Snapshot:
The role of the Eph-ephrin signalling system in the regulation of developmental patterning.
Coulthard MG, Duffy S, Down M, Evans B, Power M, Smith F, Stylianou C, Kleikamp S, Oates A, Lackmann M, Burns GF, Boyd AW.
Int J Dev Biol. 46: 375-384 (2002). [Medline entry]

Ephrin-A5 induces rounding, blebbing and de-adhesion of EphA3-expressing 293T and melanoma cells by CrkII and Rho-mediated signalling.
Lawrenson ID, Wimmer-Kleikamp SH, Lock P, Schoenwaelder SM, Down M, Boyd AW, Alewood PF, Lackmann M.
J Cell Sci. 115: 1059-1072 (2002). [Medline entry]

Crystal structure of an Eph receptor-ephrin complex.
Himanen J-P, Rajashankar KR, Lackmann M, Cowan CA, Henkemeyer M, Nikolov DB.
Nature 414: 933-938 (2001). [Medline entry]

Signals from Eph and Ephrin Proteins: A Developmental Toolkit.
Boyd AW, Lackmann M.
Sci STKE. 2001(112): RE20 (2001). [Medline entry]

The 3T3-L1 fibroblast to adipocyte conversion is accompanied by increased expression of angiopoietin-1, a ligand for tie2.
Stacker SA, Runting AS, Caesar C, Vitali A, Lackmann M, Chang J, Ward L, Wilks AF.
Growth Factors. 18:177-191 (2000). [Medline entry]

Isolation and characterization of "orphan-RTK" ligands using an integrated biosensor approach.
Lackmann M.
Methods Mol Biol. 124:335-359 (2001). [Medline entry]

Solution structure and mutagenesis of the caspase recruitment domain (CARD) from Apaf-1.
Day CL, Dupont C, Lackmann M, Vaux DL, Hinds MG.
Cell Death Differ. 6:1125-1132 (1999). [Medline entry]

An early developmental role for eph-ephrin interaction during vertebrate gastrulation.
Oates AC, Lackmann M, Power MA, Brennan C, Down LM, Do C, Evans B, Holder N, Boyd AW.
Mech Dev. 83:77-94 (1999). [Medline entry]

Biomolecular interaction analysis of IFN gamma-induced signaling events in whole-cell lysates: prevalence of latent STAT1 in high-molecular weight complexes.
Lackmann M, Harpur AG, Oates AC, Mann RJ, Gabriel A, Meutermans W, Alewood PF, Kerr IM, Stark GR, Wilks AF.
Growth Factors. 16:39-51 (1998).

Distinct subdomains of the EphA3 receptor mediate ligand binding and receptor dimerization.
Lackmann M, Oates AC, Dottori M, Smith FM, Do C, Power M, Kravets L, Boyd AW.
J Biol Chem. 273:20228-20237 (1998). [Medline entry]

Ligand for EPH-related kinase (LERK) 7 is the preferred high affinity ligand for the HEK receptor.
Lackmann M, Mann RJ, Kravets L, Smith FM, Bucci TA, Maxwell KF, Howlett GJ, Olsson JE, Vanden Bos T, Cerretti DP, Boyd AW.
J Biol Chem. 1997 Jun 27;272(26):16521-30. [Medline entry]

Structural determinants of the interaction between the erbB2 receptor and the Src homology 2 domain of Grb7.
Janes PW, Lackmann M, Church WB, Sanderson GM, Sutherland RL, Daly RJ.
J Biol Chem. 272:8490-8497 (1997). [Medline entry]

Purification of a ligand for the EPH-like receptor HEK using a biosensor-based affinity detection approach.
Lackmann M, Bucci T, Mann RJ, Kravets LA, Viney E, Smith F, Moritz RL, Carter W, Simpson RJ, Nicola NA, Mackwell K, Nice EC, Wilks AF, Boyd AW.
Proc Natl Acad Sci U S A. 93:2523-2527 (1996). [Medline entry]