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Epithelial Biochemistry Laboratory Maureen Nerrie BSc(Hons) Senior Research Officer

Current work: Preclinical studies of EGF receptor inhibitor AG1478; Structure-Function studies on the EGF/EGF receptor family EphA3 signal transduction pathways and function in normal and oncogenic development;

Research Interests: Biomek 2000 automated workstation; cytosensor technology; detection of Mycoplasma contamination of cell cultures

Publication Snapshot:
Rapid microscale enzymic semisynthesis of epidermal growth factor (EGF) analogues.
Nice EC, Domagala T, Fabri L, Nerriea M, Walker F, Jorissen RN, Burgess AW, Cui DF, Zhang YS.
Growth Factors. 20: 71-80 (2002). [Medline entry]

The use of coiled-coil interactions for the analysis and micropreparative isolation of adenomatous polyposis coli protein complexes.
Catimel B, Faux MC, Nerrie M, Rothacker J, Otvos LJ, Wade JD, Nice EC, Burgess AW.
J Pept Res. 58: 493-503 (2001). [Medline entry]

Identification of a determinant of epidermal growth factor receptor ligand-binding specificity using a truncated, high-affinity form of the ectodomain.
Elleman TC, Domagala T, McKern NM, Nerrie M, Lonnqvist B, Adams TE, Lewis J, Lovrecz GO, Hoyne PA, Richards KM, Howlett GJ, Rothacker J, Jorissen RN, Lou M, Garrett TPJ, Burgess AW, Nice EC, Ward CW.
Biochemistry 40: 8930-8939 (2001). [Medline entry]

Applications of optical biosensors to structure-function studies in the EGF/EGF receptor system.
Nice EC, Domagala T, Smyth FE, Konstantopoulos N, Nerrie M, Geleick D, Catimel B, Burgess AW.
Peptides: biology and chemistry. Proceedings of the 1998 Chinese Peptide Symposium, July 14-17, 1998, Lanzhou, China. 238-243 (2000) London. Publisher: Kluwer Academic. Editors: X-Yu Hu, R Wang and JP Tam.

Micropreparative ligand fishing with a cuvette-based optical mirror resonance biosensor.
Catimel B, Weinstock J, Nerrie M, Domagala T, Nice EC.
J Chromatogr A 869: 261-273 (2000). [Medline entry]

Kinetic analysis of the interaction between the monoclonal antibody A33 and its colonic epithelial antigen by the use of an optical biosensor. A comparison of immobilisation strategies.
Catimel B, Nerrie M, Lee FT, Scott AM, Ritter G, Welt S, Old LJ, Burgess AW, Nice EC.
J Chromatogr A 776: 15-30 (1997). [Medline entry]

Purification and characterization of a novel restricted antigen expressed by normal and transformed human colonic epithelium.
Catimel B, Ritter G, Welt S, Old LJ, Cohen L, Nerrie MA, White SJ, Heath JK, Demediuk B, Domagala T, Lee FT, Scott AM, Tu GF, Ji H, Moritz RL, Simpson RJ, Burgess AW, Nice EC.
J Biol Chem. 271: 25664-25670. (1996). [Medline entry]