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Lab head

Current Research

Laboratory staff

Selected Publications

New Stuff

AG1478 is a small molecule inhibitor of EGF receptor signalling and so may have use as a therapeutic agent against cancers in which the EGF receptor is overexpressed. We are conducting pre-clinical studies of this compound such as developing bioassays for the determination of the inhibitor's concentration and those of its metabolites in animal models and patients, developing a suitable formulation for administering AG1478 and determining its pharamacokinetics in animal models.

Lab members involved in the research:

• Ed Nice
• Janet Weinstock
• Maureen Nerrie
• Francesca Walker

Publications:
High-performance liquid chromatographic analysis of the tyrphostin AG1478, a specific inhibitor of the epidermal growth factor receptor tyrosine kinase, in mouse plasma.
Ellis AG, Nice EC, Weinstock J, Levitzki A, Burgess AW, Webster LK.
J Chromatogr B Biomed Sci Appl. 754:193-199 (2001). [Medline entry]