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We are interested in the interplay between the most frequently mutated oncogene Ras and the tumour suppressor PTEN during tumour transformation. Activated Ras inhibits PTEN expression and restoration of PTEN suppresses Ras induced tumour formation. We are identifying pathways regulating PTEN expression and its tumour suppression activities.

Lab members involved in the research:

• Hong-Jian Zhu
• Josie Iaria
• Kellie Cartledge

Collaborators:

• Heung-Chin Cheng, University of Melbourne

Publications:
Oncogenic Ras Transformation Down-Regulates the Expression of the PTEN Tumor Suppressor
Zhu H-J, Nheu T, Cheng H-C, Iaria J, Simpson RJ, Maruta H, Burgess AW
Submitted