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Selected recent publications

Crystal structure of a truncated epidermal growth factor receptor extracellular domain bound to transforming growth factor alpha
Garrett TPJ, McKern NM, Lou M, Elleman TC, Adams TE, Lovrecz GO, Zhu H-J, Walker F, Frenkel MJ, Hoyne PA, Jorissen RN, Nice EC, Burgess AW, Ward CW.
Cell. 110: 763-773 (2002). [Medline entry]

Ephrin-A5 induces rounding, blebbing and de-adhesion of EphA3-expressing 293T and melanoma cells by CrkII and Rho-mediated signalling.
Lawrenson ID, Wimmer-Kleikamp SH, Lock P, Schoenwaelder SM, Down M, Boyd AW, Alewood PF, Lackmann M.
J Cell Sci. 115: 1059-1072 (2002). [Medline entry]

Rapid microscale enzymic semisynthesis of epidermal growth factor (EGF) analogues.
Nice EC, Domagala T, Fabri L, Nerriea M, Walker F, Jorissen RN, Burgess AW, Cui DF, Zhang YS.
Growth Factors. 20: 71-80 (2002). [Medline entry]

The use of coiled-coil interactions for the analysis and micropreparative isolation of adenomatous polyposis coli protein complexes.
Catimel B, Faux MC, Nerrie M, Rothacker J, Otvos LJ, Wade JD, Nice EC, Burgess AW.
J Pept Res. 58: 493-503 (2001). [Medline entry]

Crystal structure of an Eph receptor-ephrin complex.
Himanen JP, Rajashankar KR, Lackmann M, Cowan CA, Henkemeyer M, Nikolov DB.
Nature. 414: 933-938 (2001). [Medline entry]

Regulation of Transforming Growth Factor-beta Signaling.
Zhu HJ, Burgess AW.
Mol Cell Biol Res Commun. 4: 321-330 (2001). [Medline entry]

Structural and biosensor analyses of a synthetic biotinylated peptide probe for the isolation of adenomatous polyposis coli tumor suppressor protein complexes.
Wade JD, Catimel B, Faux MC, Burgess AW, Nice E, Otvos L.
J Pept Res. 58: 204-212. (2001). [Medline entry]

Identification of a determinant of epidermal growth factor receptor ligand-binding specificity using a truncated, high-affinity form of the ectodomain.
Elleman TC, Domagala T, McKern NM, Nerrie M, Lonnqvist B, Adams TE, Lewis J, Lovrecz GO, Hoyne PA, Richards KM, Howlett GJ, Rothacker J, Jorissen RN, Lou M, Garrett TPJ, Burgess AW, Nice EC, Ward CW.
Biochemistry. 40: 8930-8939. (2001). [Medline entry]

Isolation and characterization of "orphan-RTK" ligands using an integrated biosensor approach.
Lackmann M.
Methods Mol Biol. 124:335-359 (2001). [Medline entry]

Laminin-10 mediates basal and EGF-stimulated motility of human colon carcinoma cells via alpha(3)beta(1) and alpha(6)beta(4) integrins.
Pouliot N, Nice EC, Burgess AW.
Exp Cell Res. 266: 1-10 (2001). [Medline entry]

High-performance liquid chromatographic analysis of the tyrphostin AG1478, a specific inhibitor of the epidermal growth factor receptor tyrosine kinase, in mouse plasma.
Ellis AG, Nice EC, Weinstock J, Levitzki A, Burgess AW, Webster LK.
J Chromatogr B Biomed Sci Appl. 754: 193-9 (2001). [Medline entry]

Colon cancer cells adhesion and spreading on autocrine laminin-10 is mediated by multiple integrin receptors and modulated by EGF receptor stimulation.
Pouliot N, Connolly LM, Moritz RL, Simpson RJ, Burgess AW.
Exp Cell Res. 261: 360-371 (2000). [Medline entry]

Stoichiometry, kinetic and binding analysis of the interaction between epidermal growth factor (EGF) and the extracellular domain of the EGF receptor.
Domagala T, Konstantopoulos N, Smyth F, Jorissen RN, Fabri L, Geleick D, Lax I, Schlessinger J, Sawyer W, Howlett GJ, Burgess AW, Nice EC.
Growth Factors. 18: 11-29 (2000). [Medline entry]

Characterization of a comparative model of the extracellular domain of the epidermal growth factor receptor.
Jorissen RN, Epa VC, Treutlein HR, Garrett TP, Ward CW, Burgess AW.
Protein Sci. 9: 310-324 (2000). [Medline entry]

Activation of the Ras/mitogen-activated protein kinase pathway by kinase-defective epidermal growth factor receptors results in cell survival but not proliferation.
Walker F, Kato A, Gonez LJ, Hibbs ML, Pouliot N, Levitzki A, Burgess AW.
Mol Cell Biol. 1998 Dec;18(12):7192-204. [Medline entry]

Selected past publications

Synergy between Apc min and an activated ras mutation is sufficient to induce colon carcinomas.
D'Abaco GM, Whitehead RH, Burgess AW.
Mol Cell Biol. 1996 Mar;16(3):884-91. [Medline entry]

A mutation in the epidermal growth factor receptor in waved-2 mice has a profound effect on receptor biochemistry that results in impaired lactation.
Fowler KJ, Walker F, Alexander W, Hibbs ML, Nice EC, Bohmer RM, Mann GB, Thumwood C, Maglitto R, Danks JA, Chetty R, Burgess AW, Dunn AR.
Proc Natl Acad Sci U S A. 92: 1465-1469 (1995). [Medline entry]

Platelet-derived growth factor stimulates the release of protein kinase A from the cell membrane.
deBlaquiere J, Walker F, Michelangeli VP, Fabri L, Burgess AW.
J Biol Chem. 1994 Feb 18;269(7):4812-8. [Medline entry]

Solution structure of murine epidermal growth factor determined by NMR spectroscopy and refined by energy minimization with restraints.
Montelione GT, Wuthrich K, Burgess AW, Nice EC, Wagner G, Gibson KD, Scheraga HA.
Biochemistry. 31: 236-249 (1992). [Medline entry]

Reconstitution of the high affinity epidermal growth factor receptor on cell-free membranes after transmodulation by platelet-derived growth factor.
Walker F, Burgess AW.
J Biol Chem. 266: 2746-2752 (1991). [Medline entry]

Resistance to receptor-mediated degradation of a murine epidermal growth factor analogue (EGF-Val-47) potentiates its mitogenic activity.
Walker F, Nice E, Fabri L, Moy FJ, Liu JF, Wu R, Scheraga HA, Burgess AW.
Biochemistry. 29: 10635-10640 (1990). [Medline entry]

Micropreparative LC of proteins.
Nice EC.
Nature. 348: 462-463 (1990).

Murine epidermal growth factor: structure and function.
Burgess AW, Lloyd CJ, Smith S, Stanley E, Walker F, Fabri L, Simpson RJ, Nice EC.
Biochemistry. 27: 4977-4985 (1988). [Medline entry]

Solution structure of murine epidermal growth factor: determination of the polypeptide backbone chain-fold by nuclear magnetic resonance and distance geometry.
Montelione GT, Wuthrich K, Nice EC, Burgess AW, Scheraga HA.
Proc Natl Acad Sci U S A. 84: 5226-5230 (1987). [Medline entry]

Identification of two anti-parallel beta-sheet conformations in the solution structure of murine epidermal growth factor by proton magnetic resonance.
Montelione GT, Wuthrich K, Nice EC, Burgess AW, Scheraga HA.
Proc Natl Acad Sci U S A. 83: 8594-8598 (1986). [Medline entry]

Specific binding of radioiodinated granulocyte-macrophage colony-stimulating factor to hemopoietic cells.
Walker F, Burgess AW.
EMBO J. 4: 933-939 (1985). [Medline entry]

Two forms of murine epidermal growth factor: rapid separation by using reverse-phase HPLC.
Burgess AW, Knesel J, Sparrow LG, Nicola NA, Nice EC.
Proc Natl Acad Sci U S A. 79: 5753-5757 (1982). [Medline entry]