The Epithelial Biochemistry Laboratory

Current Research

Current Research

	Intracellular signalling projects: Analysis of the APC tumour suppressor gene product Transforming Growth Factor beta receptor signalling Tumour suppressor PTEN and oncogene Ras
	Extracellular signalling projects: Role of laminin-10 in colon cancer metastasis
	EGF receptor projects: EGF receptor signalling: role in transformation and cell cycle progression Structure-Function studies on the EGF/EGF receptor family Mechanisms of EGF receptor activation Preclinical studies of EGF receptor inhibitor AG1478 Epitope mapping of Mab806 Molecular modelling of the Epidermal Growth Factor Receptor
	Ephrin signalling projects: EphA3 signal transduction pathways and function in normal and oncogenic development Structure/function analysis of Eph-receptor ephrin-ligand interactions and development of inhibitors
	Development of experimental techniques: Development of novel strategies for protein micropurification/proteomics and biosensor analysis