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Epithelial Biochemistry Laboratory Robert Jorissen BSc(Hons), PhD Research Fellow

Current work: EGF receptor modelling

Research Interests: computational structure modelling; computational ligand design; EGF receptor activation

Publication Snapshot:
Crystal structure of a truncated epidermal growth factor receptor extracellular domain bound to transforming growth factor alpha
Garrett TPJ, McKern NM, Lou M, Elleman TC, Adams TE, Lovrecz GO, Zhu H-J, Walker F, Frenkel MJ, Hoyne PA, Jorissen RN, Nice EC, Burgess AW, Ward CW.
Cell. 110: 763-773 (2002). [Medline entry]

The K252a derivatives, inhibitors for the PAK/MLK kinase family selectively block the growth of RAS transformants.
Nheu TV, He H, Hirokawa Y, Tamaki K, Florin L, Schmitz ML, Suzuki-Takahashi I, Jorissen RN, Burgess AW, Nishimura S, Wood J, Maruta H.
Cancer J. 8: 328-336 (2002). [Medline entry]

Rapid microscale enzymic semisynthesis of epidermal growth factor (EGF) analogues.
Nice EC, Domagala T, Fabri L, Nerrie M, Walker F, Jorissen RN, Burgess AW, Cui DF, Zhang YS.
Growth Factors. 20: 71-80 (2002). [Medline entry]

Modeling the epidermal growth factor -- epidermal growth factor receptor L2 domain interaction: implications for the ligand binding process.
Jorissen RN, Treutlein HR, Epa VC, Burgess AW.
J Biomol Struct Dyn. 19: 961-972 (2002). [Medline entry]

Identification of a determinant of epidermal growth factor receptor ligand-binding specificity using a truncated, high-affinity form of the ectodomain.
Elleman TC, Domagala T, McKern NM, Nerrie M, Lonnqvist B, Adams TE, Lewis J, Lovrecz GO, Hoyne PA, Richards KM, Howlett GJ, Rothacker J, Jorissen RN, Lou M, Garrett TPJ, Burgess AW, Nice EC, Ward CW.
Biochemistry. 2001 Jul 31;40(30):8930-9. [Medline entry]

Domagala T, Konstantopoulos N, Smyth F, Jorissen RN, Fabri L, Geleick D, Lax I, Schlessinger J, Sawyer W, Howlett GJ, Burgess AW, Nice EC.
Stoichiometry, kinetic and binding analysis of the interaction between epidermal growth factor (EGF) and the extracellular domain of the EGF receptor.
Growth Factors 18:11-29 (2000). [Medline entry]

Characterization of a model of a comparative model of the extracellular domain of the epidermal growth factor receptor.
Jorissen RN, Epa VC, Treutlein HR, Garrett TPJ, Ward CW, Burgess AW.
Protein Science 9: 322-336 (2000). [Medline entry]