Our laboratory is studying the signaling systems which influence the production and function of colonic cells. At present we are focusing on the EGF receptor, wnt and integrin signaling systems. We are identifying and analyzing the mutations and proteins which characterize normal and cancerous stem cells in both mice and humans. We aim to use the differences between the signaling systems of normal and cancerous colon cells to develop targeted treatments for improving outcomes for colon cancer patients.

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Studies conducted in the Colon Molecular and Cell Biology Laboratory are designed to identify and characterize the properties of genes and pathways involved in the development and progression of cancer of the colon and stomach.

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The LCCI is an international Ludwig initiative in translational research into colorectal cancer. It utilizes a resource of high quality clinical data and specimen collection from persons undergoing colorectal cancer treatment, and uses this to improve our understanding and treatment of colorectal cancer.

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There are a number of platform technologies which are utilised at the Branch.

The Central Resource for Advanced Microscopy is a service core facility to provide microscopy in support of the Institute's research and clinical programs.

The facility is equipped with two confocal microscopes, a fluorescence lifetime imaging system, a motorized wide field fluorescent inverted microscope, a motorized upright microscope and a fluorescence capable stereo microscope. Most systems are capable of live cell imaging.

We aim to assist planning experiments, training individuals the microscopy techniques they require in their research, and on occasion collaborating in their research.

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